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Artificial Endometrial Preparation for Frozen Thawed Embryo Transfer Applying Either Endometrin or Utrogestan

This study has suspended participant recruitment.
(no patient was recruited till 1/2008)
Information provided by:
Hadassah Medical Organization Identifier:
First received: June 27, 2006
Last updated: May 6, 2008
Last verified: June 2006
The transfer of frozen-thawed embryos can be performed in a natural ovulatory cycle or in a hormonally manipulated cycle with a comparable pregnancy rate of 15%-20% per ET. When a hormonally modulated ET cycle is scheduled,an artificial endometrial preparation is carried out using estrogen stimulation followed by a concomitant progesterone treatment. Two progestative drugs are currently used in conventional IVF treatment, Utrogetan and Endometrin. Although Endometrin has been be efficiently used to support the luteal phase after embryo transfer in IVF cycles, currently, there is no study that assess its efficacy for clinical use in frozen-thawed ET cycles. The present study aims to compare the outcome of frozen thawed ET cycles when either Endometrin or Utrogestan are used as the progestative substitution in an artificially prepared endometrium.

Condition Intervention Phase
Frozen Thawed Embryo Transfer
Drug: Comparison between two different progesterone administration
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Artificial Endometrial Preparation for Frozen Thawed Embryo Transfer Applying Either Endometrin or Utrogestan - a Clinical Comparative Study

Resource links provided by NLM:

Further study details as provided by Hadassah Medical Organization:

Primary Outcome Measures:
  • Pregnancy rates

Secondary Outcome Measures:
  • Lutheal hormonal profile

Estimated Enrollment: 120
Study Start Date: March 2007

Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Female

Inclusion Criteria:

  1. Patients undergoing frozen thawed ET cycles
  2. Patient has at least two embryos suitable for transfer after thawing
  3. Age 18-35 years -

Exclusion Criteria:

  1. Any known sensitivity to Endometrin or Utrogestan
  2. Endometrial thickness less than 7.5 mm after estrogen priming -
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Please refer to this study by its identifier: NCT00345306

Hadassah Medical Organization
Jerusalem, Israel, 91120
Simon Alex
Jerusalem, Israel, 91120
Sponsors and Collaborators
Hadassah Medical Organization
Principal Investigator: Alex Simon Hadassah University Hospital
  More Information Identifier: NCT00345306     History of Changes
Other Study ID Numbers: EndoUtro-HMO-CTIL
Study First Received: June 27, 2006
Last Updated: May 6, 2008

Keywords provided by Hadassah Medical Organization:
endometrial preparation

Additional relevant MeSH terms:
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs processed this record on May 23, 2017