This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Myopic Macular Haemorrhages

This study has been completed.
Information provided by:
Singapore National Eye Centre Identifier:
First received: June 26, 2006
Last updated: NA
Last verified: May 2004
History: No changes posted
  1. To identify the underlying causes of macular haemorrhages in patients with high myopia
  2. In the eyes found to have macular haemorrhages secondary to choroidal neovascularisation, we hope to identify the risk factors for the development of choroidal neovascularisation in high myopia
  3. To study the functional outcome of these eyes as assessed by visual acuity
  4. To study the morphological outcome of these eyes by clinical assessment (and fundal photography) and fluorescein angiography

Myopic Macular Haemorrhages

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Myopic Macular Haemorrhages

Resource links provided by NLM:

Further study details as provided by Singapore National Eye Centre:

Estimated Enrollment: 30
Study Start Date: June 2004
Estimated Study Completion Date: December 2006
Detailed Description:

Primary Aims

  • To identify the underlying aetiologies of macular haemorrhages in myopic eyes
  • To study the functional and morphological outcome of these eyes with macular haemorrhages 6 months later Secondary Aims
  • To study the subgroup of eyes with myopic choroidal neovascularisation (CNV), in particular the risk factors for CNV in myopes
  • To study the subgroup of eyes with macular haemorrhages in the absence of CNV

Plan of investigation:

  1. Patient with myopia (>-6.00DS) presents with loss of central vision
  2. Examination reveals a macular haemorrhage
  3. Investigations

    • Refraction
    • Axial length*
    • Fundus fluorescein angiography
    • Indocyanine green angiography*
  4. Determine if a myopic CNV is present or absent
  5. Management of patient: Treatment vs No treatment

    • Treatment being

      1. Conventional laser
      2. PDT
  6. Review at 6 months

    • BCVA
    • Clinical appearance (fundal photo)
    • FFA
  7. Review at 12 months

    • BCVA
    • Clinical appearance

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • High myopia (greater than -6.00DS)
  • Macular haemorrhage

Exclusion Criteria:

  • Macular haemorrhages from other causes eg. diabetic retinopathy, hypertensive retinopathy
  • Allergy to fluorescein or indocyanine green dyes
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00345228

Singapore National Eye Centre
Singapore, Singapore, 168751
Sponsors and Collaborators
Singapore National Eye Centre
Principal Investigator: Shu-Yen Lee, FRCSEd Singapore National Eye Centre
Study Chair: Chong-Lye Ang, FRCOphth Singapore National Eye Centre
  More Information Identifier: NCT00345228     History of Changes
Other Study ID Numbers: R347/05/2004
Study First Received: June 26, 2006
Last Updated: June 26, 2006

Keywords provided by Singapore National Eye Centre:
High myopia
Choroidal neovascularisation
Lacquer crack
Fundus fluorescein angiography
Indocyanine green angiography
Axial length

Additional relevant MeSH terms:
Pathologic Processes
Refractive Errors
Eye Diseases processed this record on August 23, 2017