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Opioid Maintenance Medications Comparison Study

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ClinicalTrials.gov Identifier: NCT00344812
Recruitment Status : Completed
First Posted : June 27, 2006
Last Update Posted : June 27, 2006
Sponsor:
Information provided by:
Johns Hopkins University

Brief Summary:
A 17 week, double-blind, randomized, parallel group, four arm design outpatient study comparing LAAM, buprenorphine and two dose levels of methadone for the treatment of opioid dependence.

Condition or disease Intervention/treatment Phase
Opioid Dependence Drug: LAAM. buprenorphine and methadone Phase 2

Study Type : Interventional  (Clinical Trial)
Enrollment : 220 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Study Start Date : January 1996
Study Completion Date : June 1998

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Study retention
  2. Drug use

Secondary Outcome Measures :
  1. Safety


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Ages Eligible for Study:   21 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion

  • age 21 to 55 years
  • diagnosis of opioid dependence by criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV)
  • evidence of recent opioid use on toxicologic screening

Exclusion

  • serious medical or psychiatric illness requiring long-term medication
  • positive pregnancy test

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00344812


Locations
United States, Maryland
Behavioral Pharmacology Research Unit; Johns Hopkins Bayview Campus
Baltimore, Maryland, United States, 21224
Sponsors and Collaborators
Johns Hopkins University
Investigators
Principal Investigator: Rolley E Johnson, PharmD Johns Hopkins University

Publications of Results:
ClinicalTrials.gov Identifier: NCT00344812     History of Changes
Other Study ID Numbers: BPR-95-07-24-03
First Posted: June 27, 2006    Key Record Dates
Last Update Posted: June 27, 2006
Last Verified: March 2006

Additional relevant MeSH terms:
Buprenorphine
Methadone
Analgesics, Opioid
Narcotics
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Narcotic Antagonists
Antitussive Agents
Respiratory System Agents