Opioid Maintenance Medications Comparison Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00344812
Recruitment Status : Completed
First Posted : June 27, 2006
Last Update Posted : June 27, 2006
Information provided by:
Johns Hopkins University

Brief Summary:
A 17 week, double-blind, randomized, parallel group, four arm design outpatient study comparing LAAM, buprenorphine and two dose levels of methadone for the treatment of opioid dependence.

Condition or disease Intervention/treatment Phase
Opioid Dependence Drug: LAAM. buprenorphine and methadone Phase 2

Study Type : Interventional  (Clinical Trial)
Enrollment : 220 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Study Start Date : January 1996
Study Completion Date : June 1998

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Study retention
  2. Drug use

Secondary Outcome Measures :
  1. Safety

Information from the National Library of Medicine

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Ages Eligible for Study:   21 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


  • age 21 to 55 years
  • diagnosis of opioid dependence by criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV)
  • evidence of recent opioid use on toxicologic screening


  • serious medical or psychiatric illness requiring long-term medication
  • positive pregnancy test

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00344812

United States, Maryland
Behavioral Pharmacology Research Unit; Johns Hopkins Bayview Campus
Baltimore, Maryland, United States, 21224
Sponsors and Collaborators
Johns Hopkins University
Principal Investigator: Rolley E Johnson, PharmD Johns Hopkins University

Publications of Results: Identifier: NCT00344812     History of Changes
Other Study ID Numbers: BPR-95-07-24-03
First Posted: June 27, 2006    Key Record Dates
Last Update Posted: June 27, 2006
Last Verified: March 2006

Additional relevant MeSH terms:
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Narcotic Antagonists
Antitussive Agents
Respiratory System Agents