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Cytogenetic Study of Ocular Melanoma

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ClinicalTrials.gov Identifier: NCT00344799
Recruitment Status : Recruiting
First Posted : June 27, 2006
Last Update Posted : September 13, 2017
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
Patients who are diagnosed with choroidal melanoma and undergo I-125 plaque or enucleation surgery consent to participate in the study. A tumor sample taken during surgery is studied in the lab for genetic features. These features and features of subjects' clinical course are recorded. Analysis of the data may identify genetic features that are indicative of prognostic factors including risk of metastasis.

Condition or disease
Choroidal Melanoma

Detailed Description:
The Jules Stein Eye Institute Ocular Melanoma Research Group is conducting cytogenetic studies of choroidal melanoma to improve the screening of biopsy samples of choroidal melanoma through cytogenetic analysis. Our goal is to identify molecular probes that specifically target regions of chromosomes that undergo changes characteristic of metastatic choroidal melanoma.

Study Design

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Molecular and Cytogenetic Studies of Ocular Melanoma
Actual Study Start Date : January 8, 2005
Estimated Primary Completion Date : August 31, 2020
Estimated Study Completion Date : August 31, 2021


Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who have been diagnosed with ocular melanoma, and underwent melanoma treatment at our facility.
Criteria

Inclusion Criteria:

  1. Patient with diagnosis of ocular melanoma
  2. Patient with local treatment plan for ocular melanoma- plaque brachytherapy or enucleation
  3. Patient 18 years of age or older
  4. Archival enucleation specimens with diagnosis of ocular melanoma

Exclusion Criteria:

  1. Patient who refuses local melanoma treatment
  2. Patient who refuses to participate in this study
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00344799


Contacts
Contact: Tara A McCannel, MD, PhD 310-206-7484 tmccannel@jsei.ucla.edu
Contact: Brenda Rangel 310 794-9962 Brangel@jsei.ucla.edu

Locations
United States, California
Jules Stein Eye Institute Recruiting
Los Angeles, California, United States, 90095
Contact: Brenda Rangel    310-794-9962    Brangel@jsei.ucla.edu   
Sponsors and Collaborators
Jonsson Comprehensive Cancer Center
Investigators
Principal Investigator: Tara M McCannel, MD, PhD Jules Stein Eye Institute, UCLA
Study Director: Bradley R Straatsma, MD, JD Jules Stein Eye Institute, UCLA
Study Chair: Lynn Gordon, MD, PhD Jules Stein Eye Institute, UCLA
Study Chair: Ben Glasgow, MD Jules Stein Eye Institute, UCLA
Study Chair: Nagesh P Rao, PhD UCLA Pathology and Laboratory Medicine
More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Jonsson Comprehensive Cancer Center
ClinicalTrials.gov Identifier: NCT00344799     History of Changes
Other Study ID Numbers: UCLA IRB#04-12-084
First Posted: June 27, 2006    Key Record Dates
Last Update Posted: September 13, 2017
Last Verified: September 2017

Keywords provided by Jonsson Comprehensive Cancer Center:
Choroidal Melanoma
Choroidal Malignant Melanoma
Ocular Melanoma
Uveal Melanoma

Additional relevant MeSH terms:
Melanoma
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Nerve Tissue
Nevi and Melanomas