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The Incidence of Breast and Other Cancers Among Female Flight Attendants

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ClinicalTrials.gov Identifier: NCT00342407
Recruitment Status : Completed
First Posted : June 21, 2006
Last Update Posted : May 9, 2018
Sponsor:
Collaborators:
Centers for Disease Control and Prevention
National Institute for Occupational Safety and Health (NIOSH/CDC)
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Cancer Institute (NCI) )

Brief Summary:

Flight attendants may be at an increased risk of breast and other cancers due to work-place exposures including cosmic radiation and circadian rhythm disruption form traveling across multiple time zones. This cancer incidence study will determine whether female flight attendants are at increased risk of breast and other cancers and whether the risk is dose-related. The study will include a cohort of approximately 10,000 women who were employed as flight attendants for one or more years.

Breast cancer cases will be identified from telephone interviews of living subjects and next-of-kin of deceased subjects, as well as from death certificates. The interview will also provide information about non-occupational risk factors for breast cancer such as parity. Both internal and external comparisons will be made. The primary analysis will evaluate the risk associated with occupational exposure within the cohort, controlling for non-occupational risk factors by stratification or modeling. The secondary analysis will compare the incidence of breast cancer in the cohort to that in the general population, with adjustment for factors such as lower parity which might increase breast cancer risk in the cohort independent of occupational exposure to cosmic radiation and circadian rhythm disruption. The risk of other ionizing radiation-related cancers, such as leukemia, lung cancer, and thyroid cancer, among flight attendants will also be evaluated. The results of the study will apply to female flight crew and frequent fliers.


Condition or disease
Thyroid Cancer Breast Cancer Non-Melanoma Skin Cancer Melanoma

Detailed Description:

Flight attendants may be at an increased risk of breast and other cancers due to work-place exposures including cosmic radiation and circadian rhythm disruption from traveling across multiple time zones. This cancer incidence study will determine whether female flight attendants are at increased risk of breast and other cancers and whether the risk is dose-related. The study will include a cohort of approximately 9,631 women who were employed as flight attendants for one or more years.

Breast cancer cases will be identified from telephone interviews of living subjects and next-of-kin of deceased subjects, as well as from death certificates. The interview will also provide information about non-occupational risk factors for breast cancer such as parity. Both internal and external comparisons will be made. The primary analysis will evaluate the risk associated with occupational exposure within the cohort, controlling for non-occupational risk factors by stratification or modeling. The secondary analysis will compare the incidence of breast cancer in the cohort to that in the general population, with adjustment for factors such as lower parity which might increase breast cancer risk in the cohort independent of occupational exposure to cosmic radiation and circadian rhythm disruption. The risk of other ionizing radiation-related cancers, such as leukemia, lung cancer, and thyroid cancer, among flight attendants will also be evaluated. The results of the study will apply to female flight crew and frequent fliers.


Study Type : Observational
Actual Enrollment : 6138 participants
Observational Model: Case-Only
Time Perspective: Other
Official Title: The Incidence of Breast and Other Cancers Among Female Flight Attendants
Study Start Date : November 6, 2001

Resource links provided by the National Library of Medicine

U.S. FDA Resources




Primary Outcome Measures :
  1. Breast and other cancers [ Time Frame: Time of questionnaire, time of death ]
    survival



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 100 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Female flight attendants
Criteria
  • INCLUSION CRITERIA:

Employed as a flight attendant for one or more years by Pan AM before Pan Am ceased operation in 1991. For flight attendants who transferred to Pan Am from National Airlines when Pan Am bought National Airlines in 1981, the time employed as a flight attendant at National Airlines will be counted towards the one year minimum.

A U.S. citizen when they began working at Pan Am (or National Airlines, if the flight attendant transferred to Pan AM from National Airlines).

Worked at least one day after January 1, 1953.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00342407


Locations
United States, Ohio
National Institute for Occupational Safety and Health (NIOSH)
Cincinnati, Ohio, United States, 45226
Sponsors and Collaborators
National Cancer Institute (NCI)
Centers for Disease Control and Prevention
National Institute for Occupational Safety and Health (NIOSH/CDC)
Investigators
Principal Investigator: Mark P Little, Ph.D. National Cancer Institute (NCI)

Publications:
Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT00342407     History of Changes
Other Study ID Numbers: 999902039
02-C-N039
First Posted: June 21, 2006    Key Record Dates
Last Update Posted: May 9, 2018
Last Verified: April 27, 2018

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Cancer Institute (NCI) ):
Cancer Risk
Cosmic Radiation
Airlines
Flight Attendants
Circadian Rhythm

Additional relevant MeSH terms:
Thyroid Neoplasms
Skin Neoplasms
Endocrine Gland Neoplasms
Neoplasms by Site
Neoplasms
Head and Neck Neoplasms
Endocrine System Diseases
Thyroid Diseases
Skin Diseases