Maternal and Umbilical Cord Hormone Concentrations in Twin and Singleton Pregnancies
This study will examine levels of hormones, such as estrogen and testosterone, in maternal and umbilical cord blood to compare hormones between mothers who are having twins and mothers who are having one baby. It will investigate whether hormone levels in twin versus singleton pregnancies influence the babies' risk of developing breast, prostate, and testicular cancers later in life.
Pregnant women 18 years of age and older who do not have preeclampsia, chronic hypertension, pre-pregnancy or gestational diabetes, thyroid disease, or other major pregnancy complications are eligible for this study. Participants will be recruited from the obstetrics and gynecology practice at the Dartmouth Hitchcock Medical Center in Lebanon, New Hampshire.
Participants will have a blood sample drawn from their arm during their third trimester prenatal visit and again when they are admitted to the hospital for delivery. After the baby is born, a blood sample will be collected from the cut umbilical cord. Information about the pregnancy and delivery will be collected from the mother's medical chart, and information about the baby's size will be obtained from the baby's medical chart.
|Study Design:||Observational Model: Case-Control
Time Perspective: Prospective
|Official Title:||Study of Maternal and Umbilical Cord Hormone Concentrations in Monochorionic and Dichorionic Pregnancies|
- Hormone concentrations [ Time Frame: Pregnancy ]
|Study Start Date:||November 19, 2003|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00341263
|United States, New Hampshire|
|Darmouth-Hitchcock Medical Center|
|Hanover, New Hampshire, United States, 03756|
|Principal Investigator:||Rebecca Troisi, D.Sc.||National Cancer Institute (NCI)|