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Genetic Analysis of Hereditary Non-Syndromic Oral Clefts

This study is currently recruiting participants.
Verified May 9, 2017 by National Institutes of Health Clinical Center (CC) ( National Human Genome Research Institute (NHGRI) )
Sponsor:
ClinicalTrials.gov Identifier:
NCT00340626
First Posted: June 21, 2006
Last Update Posted: July 2, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Human Genome Research Institute (NHGRI) )
  Purpose
In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease.

Condition
Hereditary Oral Clefts

Study Type: Observational
Official Title: Genetic Analysis of Hereditary Non-Syndromic Oral Clefts

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC) ( National Human Genome Research Institute (NHGRI) ):

Primary Outcome Measures:
  • Genetic risk factor for oral clefts

Estimated Enrollment: 1000
Study Start Date: June 25, 1997
Detailed Description:
In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
  • INCLUSION CRITERIA:

Enrollment in this study will be limited to individuals with non-syndromic unilateral or bilateral cleft lip with or without cleft palate and their unaffected relatives, from families which meet the following criteria:

  1. A cluster of 2 or more affected first degree relatives, such as a parent and two offspring or 2 siblings, or
  2. The occurrence of oral clefts in each of 2 generations in either the proband's paternal or maternal lineages.

EXCLUSION CRITERIA:

Families with syndromic forms of oral clefts.

Individuals unable to provide consent, except for cases who are children and mentally impaired persons with consenting parents or guardians.

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00340626


Contacts
Contact: Joan Bailey-Wilson, Ph.D. (443) 740-2921 jebw@nhgri.nih.gov

Locations
Syrian Arab Republic
IBN Al Nafees Hospital Recruiting
Damascus, Syrian Arab Republic
Sponsors and Collaborators
National Human Genome Research Institute (NHGRI)
Investigators
Principal Investigator: Joan Bailey-Wilson, Ph.D. National Human Genome Research Institute (NHGRI)
  More Information

Publications:
Responsible Party: National Human Genome Research Institute (NHGRI)
ClinicalTrials.gov Identifier: NCT00340626     History of Changes
Other Study ID Numbers: 999997035
OH97-HG-N035
First Submitted: June 19, 2006
First Posted: June 21, 2006
Last Update Posted: July 2, 2017
Last Verified: May 9, 2017

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Human Genome Research Institute (NHGRI) ):
Whole Genome Sequencing
Cleft Palate