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A Genome-Wide Scan For Quantitative Trait Loci of Serum Bilirubin - A Framingham Study

This study has been completed.
Information provided by:
National Institutes of Health Clinical Center (CC) Identifier:
First received: June 19, 2006
Last updated: April 19, 2017
Last verified: July 23, 2013
Studies have shown that there is a significant association between serum bilirubin concentrations and risk of coronary artery disease (CAD). So far, no linkage analysis in humans between serum bilirubin and DNA markers has been reported. The purpose of this protocol is to identify chromosome regions that contain quantitative trait loci (QTL) involved in serum bilirubin metabolism and bilirubin concentration. In the Framingham Study, a 10cM genome scan (about 400 markers) has been conducted in more than three hundred families. Serum bilirubin was measured in the first and second exams of the Framingham Offspring. These data provide us the opportunity to undertake linkage analyses to map QTL of serum bilirubin.


Study Type: Observational
Official Title: A Genome-Wide Scan For Quantitative Trait Loci of Serum Bilirubin - A Framingham Study

Resource links provided by NLM:

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 99999999
Study Start Date: October 26, 2001
Estimated Study Completion Date: July 23, 2013
Detailed Description:
Many studies showed that there is a significant relationship between serum bilirubin levels and risk of coronary artery disease (CAD). We carried out a genome-wide scan for quantitative trait loci of serum bilirubin through the 330 extended Framingham families and found significant evidence of linkage of serum bilirubin to chromosome 2q telomere where an important candidate gene, Uridine diphosphate glycosyltransferase 1 gene (UGT1A1), resides. The purposes of this protocol are to confirm linkage between serum bilirubin and UGT1A1, mathematical modeling and association studies between the genotypes of UGT1A1 and CAD.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

The study population will include the members of the 330 Framingham Study families and 1888 random individuals.

The Original Cohort will also be included.

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Please refer to this study by its identifier: NCT00340509

United States, Maryland
National Heart, Lung and Blood Institute (NHLBI), 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Gang PH Zheng, Ph.D. National Heart, Lung, and Blood Institute (NHLBI)
  More Information

Publications: Identifier: NCT00340509     History of Changes
Other Study ID Numbers: 999902016
Study First Received: June 19, 2006
Last Updated: April 19, 2017

Keywords provided by National Institutes of Health Clinical Center (CC):
CHD Risk
Gene Mapping

Additional relevant MeSH terms:
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs processed this record on May 25, 2017