Exposure to Neurotoxins as Risk Factors for Amyotrophic Lateral Sclerosis
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|ClinicalTrials.gov Identifier: NCT00339976|
Recruitment Status : Completed
First Posted : June 21, 2006
Last Update Posted : July 2, 2017
|Condition or disease|
|Amyotrophic Lateral Sclerosis ALS|
Objective: The objective of this proposal is linkage with the National Death Index (NDI) for cases from a study that was conducted in the early 1990's. The purpose of the initial study was to examine the role that lead and other exposures, including mercury and solvents, play in the etiology of amyotrophic lateral sclerosis (ALS).
Study population: The study involved 110 ALS cases and 256 population based controls, recruited in New England between 1993 and 1996. Data collection involved an interview, blood collection, and measurement of bone lead using x-ray fluorescence.
Design and outcome parameters: The results of this study suggested that lead exposure was a risk factor for ALS. Compared to controls, cases were more likely to have occupational lead exposure, and both blood and bone lead levels were higher in cases. We are presently analyzing data on other neurotoxic exposures including mercury, solvents, and pesticides. In order to investigate prognosis, we would like to determine the date of death by searching the National Death Index. This information will enable us to evaluate the relationship of neurotoxic exposures to ALS prognosis.
|Study Type :||Observational|
|Estimated Enrollment :||0 participants|
|Official Title:||Ascertainment of Death in ALS Patients|
|Study Start Date :||August 6, 2002|
|Estimated Study Completion Date :||April 21, 2008|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00339976
|United States, North Carolina|
|NIEHS, Research Triangle Park|
|Research Triangle Park, North Carolina, United States, 27709|