Group 1: Offspring of mothers with diabetes during pregnancy.
Maternal diagnosis of type 2 diabetes (by WHO criteria after a 75g OGTT or on clinical grounds with at least one random plasma glucose greater than 200mg/dl) before or during the index pregnancy.
Group 2: Offspring of mothers with diabetes diagnosed following pregnancy.
Maternal diagnosis of type 2 diabetes (by WHO criteria after a 75g OGTT or on clinical grounds with at least one random plasma glucose greater than 200 mg/dl) after the index pregnancy.
It is important to also ensure that these mothers did not have any major disturbance in glucose tolerance during the index pregnancy and a record of normal glucose tolerance after the index pregnancy; therefore they will only be included if there are also:
Adequate records of glucose testing during the index pregnancy and these records are not in keeping with a diagnosis of gestational diabetes (by either WHO criteria if a 75g oral glucose tolerance test has been carried out).
At least one non-diabetic OGTT after the index pregnancy.
- History of weight loss for child (greater than 2kg over last 6 months).
- Presence of other major illnesses which might interfere with appetite or food intake in mother or child.
- Child not living with mother.