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The Usefulness of HyperQ Recordings for the Early Diagnosis of Acute Coronary Syndrome in Patients Presenting With Chest Pain

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2007 by Sheba Medical Center.
Recruitment status was:  Recruiting
Information provided by:
Sheba Medical Center Identifier:
First received: June 19, 2006
Last updated: January 14, 2007
Last verified: January 2007
The purpose of the study is to assess the usefulness of high Frequency mid-QRS analysis in identifying the ischemic origin of patients presenting to the Emergency Room (ER)with Chest pain.

Condition Phase
Acute Coronary Syndrome
Phase 3

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: The Usefulness of HyperQ Recordings for the Early Diagnosis of Acute Coronary Syndrome in Patients Presenting With Chest Pain

Resource links provided by NLM:

Further study details as provided by Sheba Medical Center:

Estimated Enrollment: 50
Study Start Date: June 2006
Estimated Study Completion Date: January 2007
Detailed Description:


Chest pain is the leading cause of urgent admission to the Emergency Department (ED) in western countries.Acute Coronary Syndrome(ACS) continues to be among the most difficult to predict or diagnose. Misdiagnoses may lead to discharge of patients with ACS, who should have been admitted as well as costly unnecessary hospitalizations of patients who do not have ACS.


To evaluate the usefulness of High Frequency mid-QRS analysis in identifying the ischemic patients out of all patients presenting to the Emergency Room (ER) with chest pain.


A continuous High Frequency Mid-QRS recording will be performed using the HyperQ System (BSP Ltd.) and compared to clinical, electrophysiologic and laboratory results. The golden standards used to compare the methods will be either CT-Angio, Echocardiography or Cardiac SPECT. A follow-up inquiry will be performed after 3 months and Coronary Angiography results will be sought and compared as well.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age ≥18 years
  • Patients with chest pain, with possible ACS.
  • Patients admitted to the ‘chest pain unit’
  • Chest pain appeared within 24 hours prior to admission to the ‘chest pain unit’
  • No history of trauma or any other evident medical cause of chest pain
  • Signed an Informed Consent

Exclusion Criteria:

  • Implanted pacemaker or defibrillator
  • History of trauma or other evident medical cause of chest pain
  • Patients admitted to Intensive Cardiac Care Unit or intermediate Cardiac Care Unit
  • Patients discharged from the ER
  • Patients with Bundle-Branch-Block or other intra-ventricular delay of more than 120 mSec
  Contacts and Locations
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Please refer to this study by its identifier: NCT00339105

The Chest Pain Unit, ER, Sheba Medical Center, Tel-Hashomer
Ramat-Gan, Israel
Sponsors and Collaborators
Sheba Medical Center
Principal Investigator: Shlomi Matetzky, MD Head of Chest Pain Unit, ER, Sheba Medical Center
  More Information

Additional Information:
Publications: Identifier: NCT00339105     History of Changes
Other Study ID Numbers: SHEBA-06-4114-SM-CTIL 
Study First Received: June 19, 2006
Last Updated: January 14, 2007
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Sheba Medical Center:

Additional relevant MeSH terms:
Acute Coronary Syndrome
Chest Pain
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on December 07, 2016