Effects of Continuous Airway Pressure on the Ability to Heat and Humidify Air
We hypothesize that continuous positive pressure applied to the airway will decrease the ability of the nose to warm and humidify inspired air compared to zero or negative pressure.
We will use continuous positive airway pressure (CPAP), a device commonly used to treat patients with sleep apnea, to vary the pressure in the airway and determine if increased pressure decreases the ability to warm and humidify inspired air. If our hypothesis is correct, it may explain the reason why CPAP is poorly tolerated in patients with sleep apnea; i.e., less ability to warm and humidify air leading to more nasal mucosal irritation.
|Healthy||Procedure: Continuous positive airway pressure (CPAP) at -5, 0, 5 and 10 cm of water|
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
|Official Title:||Effects of Continuous Airway Pressure on the Ability to Heat and Humidify Air|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00338403
|United States, Illinois|
|University of Chicago|
|Chicago, Illinois, United States, 60637|
|Principal Investigator:||Robert M Naclerio, MD||University of Chicago|