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Neuroendocrine Dysfunction in Traumatic Brain Injury: Correlation With Cognitive Dysfunction and Repair

This study has been terminated.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00336726
First Posted: June 14, 2006
Last Update Posted: March 24, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Denver Research Institute
  Purpose
Traumatic Brain Injury (TBI) is a neurologic disorder cuased by physical trauma to the brain. Neuroendocrine abnormalities in these patients have been reported, including central hypogonadism within hours of the insult and eventual recovery of the hypothalamic-pituitary-gonadal axis with recovery of cognitive function to baseline. This pilot study will measure hormonal level of neuroendocine function at the time of TBI and various time points during recovery.

Condition
Traumatic Brain Injury

Study Type: Observational
Study Design: Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Denver Research Institute:

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   21 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Male subjects having had a recent traumatic brain injury
Criteria

Inclusion Criteria:

  • Male subjects having had a recent traumatic brain injury.

Exclusion Criteria:

  • Currently receivng sex steroids, glucocorticoids, or have an inability to complete the neurobehavioral assessment.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00336726


Sponsors and Collaborators
Denver Research Institute
Investigators
Principal Investigator: Margaret E Wierman, MD Dept. of Veterans Affairs/University of Colorado HSC
  More Information

Responsible Party: Margaret Wierman, M.D., VA Medical Center
ClinicalTrials.gov Identifier: NCT00336726     History of Changes
Other Study ID Numbers: GR-735
First Submitted: June 13, 2006
First Posted: June 14, 2006
Last Update Posted: March 24, 2011
Last Verified: December 2004

Additional relevant MeSH terms:
Brain Injuries
Brain Injuries, Traumatic
Cognitive Dysfunction
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Craniocerebral Trauma
Trauma, Nervous System
Wounds and Injuries
Cognition Disorders
Neurocognitive Disorders
Mental Disorders