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Neuroendocrine Dysfunction in Traumatic Brain Injury: Correlation With Cognitive Dysfunction and Repair

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ClinicalTrials.gov Identifier: NCT00336726
Recruitment Status : Terminated
First Posted : June 14, 2006
Last Update Posted : March 24, 2011
Information provided by:

Study Description
Brief Summary:
Traumatic Brain Injury (TBI) is a neurologic disorder cuased by physical trauma to the brain. Neuroendocrine abnormalities in these patients have been reported, including central hypogonadism within hours of the insult and eventual recovery of the hypothalamic-pituitary-gonadal axis with recovery of cognitive function to baseline. This pilot study will measure hormonal level of neuroendocine function at the time of TBI and various time points during recovery.

Condition or disease
Traumatic Brain Injury

Study Design

Study Type : Observational
Time Perspective: Prospective

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U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   21 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Male subjects having had a recent traumatic brain injury

Inclusion Criteria:

  • Male subjects having had a recent traumatic brain injury.

Exclusion Criteria:

  • Currently receivng sex steroids, glucocorticoids, or have an inability to complete the neurobehavioral assessment.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00336726

Sponsors and Collaborators
Denver Research Institute
Principal Investigator: Margaret E Wierman, MD Dept. of Veterans Affairs/University of Colorado HSC
More Information

Responsible Party: Margaret Wierman, M.D., VA Medical Center
ClinicalTrials.gov Identifier: NCT00336726     History of Changes
Other Study ID Numbers: GR-735
First Posted: June 14, 2006    Key Record Dates
Last Update Posted: March 24, 2011
Last Verified: December 2004

Additional relevant MeSH terms:
Brain Injuries
Brain Injuries, Traumatic
Cognitive Dysfunction
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Craniocerebral Trauma
Trauma, Nervous System
Wounds and Injuries
Cognition Disorders
Neurocognitive Disorders
Mental Disorders