Molecular Mechanisms and Diagnosis of Mastocytosis
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|ClinicalTrials.gov Identifier: NCT00336076|
Recruitment Status : Completed
First Posted : June 12, 2006
Last Update Posted : November 7, 2016
|Condition or disease||Intervention/treatment|
|Mastocytosis||Other: Collection of blood and bone marrow|
|Study Type :||Observational|
|Actual Enrollment :||136 participants|
|Official Title:||Investigation of Cellular and Molecular Pathologic Mechanisms in Mast Cell Disorders.|
|Study Start Date :||July 2004|
|Actual Primary Completion Date :||December 2008|
|Actual Study Completion Date :||July 2009|
Participants evaluated for mastocytosis
Observational study of all patients referred for suspected mast cell disease. Collection of blood or bone marrow for analysis during diagnostic procedures.
Other: Collection of blood and bone marrow
5-8 cc blood or bone marrow was additionally collected for analysis during diagnostic procedures. No assigned interventions.
- Proportion of the patients with clonal and non-clonal mast cell disorders [ Time Frame: 1 week ]Patients were categorized into one of the clonal and non-clonal mast cell disorder categories after availability of diagnostic data
- Proportion of KIT D816V mutation in blood, bone marrow and sorted mast cells [ Time Frame: 1 week ]KIT D816V mutation was assessed in patient samples containing various proportions of neoplastic mast cells.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00336076
|United States, Michigan|
|University of Michigan|
|Ann Arbor, Michigan, United States, 48109|
|Principal Investigator:||Cem Akin, M.D., Ph.D.||University of Michigan|