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Open Label Study Assessing Effectiveness Of Amlodipine/Atorvastatin In Subjects With Hypertension and Dyslipidaemia (JEWEL I)

This study has been completed.
Information provided by:
Pfizer Identifier:
First received: February 28, 2006
Last updated: January 6, 2010
Last verified: April 2007
To evaluate the effectiveness of amlodipine/atorvastatin therapy by assessing the percentage of subjects who reach target blood pressure (BP) and LDL-C targets as defined by their governing guidelines.

Condition Intervention Phase
Drug: Amlodipine/Atorvastatin
Phase 3

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: An International, Multicentre, Open Label Study To Assess The Effectiveness Of Amlodipine -Atorvastatin Combination In Subjects With Hypertension and Dyslipidaemia. (The JEWEL Study)

Resource links provided by NLM:

Further study details as provided by Pfizer:

Primary Outcome Measures:
  • To evaluate the number of patients who reach target blood pressure (BP) and
  • LDL-C targets as defined by their governing guidelines.

Secondary Outcome Measures:
  • To assess changes from baseline to end of treatment for the following efficacy
  • parameters: LDL-C, total cholesterol (TC), triglycerides, high-density lipoprotein
  • cholesterol (HDL-C), HDL-C/LDL-C ratio, TC/HDL-C ratio. Systolic Blood Pressure
  • (SBP) and Diastolic Blood Pressue (DBP).

Estimated Enrollment: 1250
Study Start Date: October 2004
Estimated Study Completion Date: September 2005

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients who are above target LDL-C and BP who are eligible for treatment

Exclusion Criteria:

  • High liver enzymes
  Contacts and Locations
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Please refer to this study by its identifier: NCT00330785

  Show 125 Study Locations
Sponsors and Collaborators
Study Director: Pfizer Call Center Pfizer
  More Information

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00330785     History of Changes
Other Study ID Numbers: A3841018
Study First Received: February 28, 2006
Last Updated: January 6, 2010

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases
Lipid Metabolism Disorders
Metabolic Diseases
Atorvastatin Calcium
Amlodipine, atorvastatin drug combination
Anticholesteremic Agents
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Enzyme Inhibitors
Antihypertensive Agents
Calcium Channel Blockers
Membrane Transport Modulators
Vasodilator Agents processed this record on May 25, 2017