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Effects of Red Wine and Cognac on Coronary Circulation

This study has been completed.
University of Tampere
Information provided by:
University of Turku Identifier:
First received: May 24, 2006
Last updated: NA
Last verified: September 2004
History: No changes posted
Red wine consumption is associated with reduced cardiovascular disease mortality, and the cardioprotective properties may be partly related to its ability to improve endothelial function. The purpose of this study was to determine whether moderate doses of red wine, de-alcoholized red wine and cognac improve coronary flow reserve.

Condition Intervention
Behavioral: red wine and cognac consumption

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind
Primary Purpose: Treatment
Official Title: Effects of Red Wine and Cognac on Coronary Circulation

Further study details as provided by University of Turku:

Primary Outcome Measures:
  • coronary flow reserve
  • plasma antioxidant capacity

Estimated Enrollment: 25
Study Start Date: October 2004
Estimated Study Completion Date: April 2005
Detailed Description:

Moderate consumption of red wine is associated with reduced coronary artery disease mortality. Cardioprotective effects of red wine may be partly related to its ability to improve endothelial function. Red wine increases endothelium-dependent flow-mediated dilatation of the brachial artery acutely after ingestion. Moreover, a heavy dose of red wine (ethanol 1.0 g/kg) has been shown to increase coronary flow reserve (CFR) as measured with transthoracic Doppler echocardiography. CFR depicts the relative increase of coronary blood flow in response to maximal myocardial hyperemia induced by adenosine. It is reduced in atherosclerosis and various conditions associated with the dysfunction of coronary microcirculation, such as diabetes and hypercholesterolemia.

Both ethanol and antioxidative polyphenols have been implicated in beneficial endothelial effects of red wine. However, their relative contributions remain uncertain in vivo. It has been suggested that red wine has stronger vasoactive properties than other alcohol beverages, and even de-alcoholized red wine may be sufficient to improve flow-mediated dilatation of the brachial artery. Cognac is also known to contain polyphenols, but its effects on coronary circulation have not been evaluated.

The purpose of this randomized controlled cross-over study was to determine with transthoracic echocardiography whether moderate doses of red wine improve CFR in response to adenosine in healthy humans. We also studied contributions of ethanol and antioxidants by comparing the effects of equal doses of alcoholic and de-alcoholized red wine, and cognac on the plasma antioxidant capacity and CFR.


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy males

Exclusion Criteria:

  • smoking, medication of any kind
  Contacts and Locations
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Please refer to this study by its identifier: NCT00330213

Dept. Clinical Physiology and Nuclear Medicine, Turku University Hospital
Turku, Finland, FIN-20520
Sponsors and Collaborators
University of Turku
University of Tampere
Principal Investigator: Tuomas O Kiviniemi, MD Dept. Clinical Physiology and Nuclear Medicine, Turku University Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00330213     History of Changes
Other Study ID Numbers: KLF-RW-06
Study First Received: May 24, 2006
Last Updated: May 24, 2006

Keywords provided by University of Turku:
red wine
coronary reactivity processed this record on May 25, 2017