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Detection of Topographic Residual Acuity in Patients With Age Related Macular Degeneration

This study has been completed.
Information provided by:
University Health Network, Toronto Identifier:
First received: May 23, 2006
Last updated: May 22, 2008
Last verified: November 2006

Standard perimetry provides information on topographical retinal sensitivity to light stimuli, however the said locus is not necessarily the preferred locus for fixation. Standard perimetry could also be used as a way for macular scotoma mapping, indirectly showing the fixation locus. Topographic acuity at the preferred retinal locus can be determined if correlation between loci with high sensitivity, eccentric fixation loci and potential visual acuity measurements are correlated.


Determination of visual acuity at preferred retinal locus in Low Vision patients with ARMD using eye standard automated and computerized perimetry methods.

Condition Intervention
Age-Related Macular Degeneration Procedure: perimetry

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic

Resource links provided by NLM:

Further study details as provided by University Health Network, Toronto:

Primary Outcome Measures:
  • Location of eccentric retinal locus of highest fixation accuracy

Secondary Outcome Measures:
  • Location of eccentric locus with best retinal sensitivity

Estimated Enrollment: 30
Study Start Date: April 2006
Study Completion Date: January 2008
Primary Completion Date: January 2008 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • AMD with documented pathology
  • Low Vision both eyes
  • BCVA 20/50-20/400 in best eye

Exclusion Criteria:

  • Cognitive impairment
  • Other retinal pathology
  • Previous retinal surgery
  • Significant media opacity
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00329277

Canada, Ontario
Dr S N Markowitz
Toronto, Ontario, Canada, M6H 2H1
Sponsors and Collaborators
University Health Network, Toronto
Principal Investigator: Samuel Markowitz, MD University Health Network, Toronto
  More Information Identifier: NCT00329277     History of Changes
Other Study ID Numbers: SNM200601
Study First Received: May 23, 2006
Last Updated: May 22, 2008

Keywords provided by University Health Network, Toronto:
age-related macular degeneration
preferred retinal locus
macular perimetry

Additional relevant MeSH terms:
Macular Degeneration
Retinal Degeneration
Retinal Diseases
Eye Diseases processed this record on September 21, 2017