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Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine

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ClinicalTrials.gov Identifier: NCT00328900
Recruitment Status : Unknown
Verified April 2007 by Rikshospitalet University Hospital.
Recruitment status was:  Recruiting
First Posted : May 24, 2006
Last Update Posted : June 1, 2012
Sponsor:
Information provided by:
Rikshospitalet University Hospital

Brief Summary:
24 patients randomly divided into two groups, one of the groups receiving atropine in addition to the planned anaesthesia. Skin conductance parameters to be compared between the two groups.

Condition or disease Intervention/treatment Phase
Hemorrhoids Fissure in Ano Drug: Administration of 0,7 mg of atropine Device: Measurement of skin conductance with Pain detector Not Applicable

Detailed Description:

Skin conductance (SC), in terms of numbers of skin conduction fluctuations (NSCF), amplitude and mean skin conductance level, reflect the activity in the sympathetic postganglionic cholinergic fibers which innervate the palmar and plantar sweat glands. Skin conductance, especially numbers of skin conductance fluctuations, may be a promising tool to monitor anesthesia. Atropine, an anticholinergic agent, acts as an antagonist on the muscarinic receptors of the sweat glands and inhibits their secretion in a dose-dependent way. The aim of this study was to find out to what degree SC is influenced by i.v. administration of atropine.

Study hypothesis: SC is not influenced by i.v. administration of atropine.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 24 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Study Start Date : January 2006

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Number of skin conductance fluctuations


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients in ASA-group 1-2
  • Operations (anal fissures, anal fistulas and haemorrhoids) lasting for less than one hour
  • informed consent
  • BMI <30

Exclusion Criteria:

  • Patients using any medication known to influence the autonomous nervous system
  • Patients with contraindications to atropine (e.i. fibrillation, glaucoma ect)
  • BMI >30
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00328900


Contacts
Contact: Hanne Storm, PhD +47 23074398 hanne.storm@medisin.uio.no

Locations
Norway
Ulleval University Hospital Recruiting
Oslo, Norway, 0407
Contact: Hanne Storm, PhD    +47 23074398    hanne.storm@medisin.uio.no   
Sponsors and Collaborators
Rikshospitalet University Hospital
Investigators
Study Director: Hanne Storm, PhD Rikshospitalet University Hospital

Responsible Party: Hanne Storm MD.PhD, Rikshospitalet, UIO
ClinicalTrials.gov Identifier: NCT00328900     History of Changes
Other Study ID Numbers: S-03113
First Posted: May 24, 2006    Key Record Dates
Last Update Posted: June 1, 2012
Last Verified: April 2007

Keywords provided by Rikshospitalet University Hospital:
Galvanic skin response
Anesthesia
Atropine

Additional relevant MeSH terms:
Hemorrhoids
Fissure in Ano
Rectal Diseases
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Vascular Diseases
Cardiovascular Diseases
Anus Diseases
Atropine
Adjuvants, Anesthesia
Anti-Arrhythmia Agents
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Asthmatic Agents
Respiratory System Agents
Mydriatics
Parasympatholytics
Muscarinic Antagonists
Cholinergic Antagonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action