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Plasma Levels of Matrix Metalloproteinases (MMPs) and Degree of DNA Fragmentation in Pseudoexfoliation (PEX) Glaucoma

This study has been completed.
Information provided by:
University Hospital, Basel, Switzerland Identifier:
First received: May 17, 2006
Last updated: September 25, 2008
Last verified: September 2008

Glaucoma is a worldwide leading cause of blindness. The key feature of this ocular neuropathy is characterized by an excavating optic nerve head. Loss of retinal ganglion cells is the final end point in blinding diseases of the optic nerve such as glaucoma. It is known that neuronal cell death in glaucoma occurs by apoptotic mechanism. In earlier studies, the investigators demonstrated that the process of apoptosis is reflected in circulating leukocytes by different parameters, like differential messenger ribonucleic acid (mRNA) expression and an increased fragmentation of the deoxyribonucleic acid (DNA). Such alterations point out a relationship between cellular stress and apoptotic events.

Based on the results of mRNA-expression, the investigators also expect alterations on the protein level.

This study is, therefore, designed to characterize the proteome related to the proteins involved in cell death related pathways.

Thus the expression pattern of several proteins in leukocytes from patients with primary open angle glaucoma will be analyzed by techniques like Western-blot and tandem mass spectrometry. These samples will be compared with healthy controls. In addition, they will be also compared with samples from patients with Parkinson's disease. Since glaucoma is a neurodegenerative disease, these patients will be included as a positive control in this study.

Pseudoexfoliation Syndrome Glaucoma

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Plasma Levels of Matrix Metalloproteinases and Degree of DNA Fragmentation in Patients With Pseudoexfoliation Syndrome and Open-Angle Glaucoma (PEXG)

Resource links provided by NLM:

Further study details as provided by University Hospital, Basel, Switzerland:

Enrollment: 60
Study Start Date: June 2005
Study Completion Date: April 2008
Primary Completion Date: April 2008 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with pseudoexfoliation

Inclusion Criteria:

  • German native speakers
  • Age between 18-80 years
  • Pseudoexfoliation syndrome
  • Pseudoexfoliation syndrome with open-angle glaucoma
  • Primary open-angle glaucoma

Exclusion Criteria:

  • Any history of ocular or systemic diseases other than glaucoma or of drug or alcohol abuse.
  • Any condition potentially interfering with the visual field results. Visual fields will be obtained from the chart.
  • Any mentally impaired patient.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00327613

University Eye Clinic Basel
Basel, BS, Switzerland, 4031
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Study Director: Selim Orgül, MD University Hospital, Basel, Switzerland
  More Information

Responsible Party: Selim Orgul, University Hospital, Basel, Switzerland Identifier: NCT00327613     History of Changes
Other Study ID Numbers: 066-WUK-2005-001
Study First Received: May 17, 2006
Last Updated: September 25, 2008

Keywords provided by University Hospital, Basel, Switzerland:
DNA degradation
Healthy subjects

Additional relevant MeSH terms:
Exfoliation Syndrome
Pathologic Processes
Ocular Hypertension
Eye Diseases
Iris Diseases
Uveal Diseases processed this record on June 23, 2017