Effect of Intensive Periodontal Therapy on Vascular Function
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|ClinicalTrials.gov Identifier: NCT00327561|
Recruitment Status : Completed
First Posted : May 18, 2006
Last Update Posted : May 18, 2006
The hypothesis of the existence of a causal association between the systemic infectious/inflammatory burden represented by periodontitis and endothelial function assessed by flow mediated dilatation of the brachial artery (FMD) is the subject of the proposed investigation.
The objective of this randomized controlled clinical trial is to evaluate the effects of periodontal therapy on endothelial function assessed by Flow mediated dilatation (FMD).
The rationale for this project is twofold:
- Establish the extent of acute systemic inflammation and endothelial dysfunction associated with the delivery of subgingival instrumentation for the treatment of chronic periodontitis
- Establish whether or not improved control of chronic periodontal infections results in improved endothelial function and thus the existence of a causal association between periodontitis and endothelial dysfunction.
|Condition or disease||Intervention/treatment||Phase|
|Periodontitis||Procedure: Intensive periodontal therapy Procedure: Community based periodontal therapy||Phase 3|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||120 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Effects of Non-Surgical Periodontal Therapy on Endothelial Function A Randomized Controlled Clinical Trial|
|Study Start Date :||September 2003|
|Study Completion Date :||March 2005|
- Flow mediated dilatation of the brachial artery
- Serum inflammatory and endothelial function markers
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00327561
|UCL Eastman Dental Institute and Hospital|
|London, United Kingdom, WC1X 8LD|
|UCL Vascular Biology Laboratory - Great Ormond Street Hospital|
|London, United Kingdom|
|Principal Investigator:||Maurizio Tonetti, DMD PhD||University College London Hospitals and University of Connecticut Health Center|