Effect of Intensive Periodontal Therapy on Vascular Function
The hypothesis of the existence of a causal association between the systemic infectious/inflammatory burden represented by periodontitis and endothelial function assessed by flow mediated dilatation of the brachial artery (FMD) is the subject of the proposed investigation.
The objective of this randomized controlled clinical trial is to evaluate the effects of periodontal therapy on endothelial function assessed by Flow mediated dilatation (FMD).
The rationale for this project is twofold:
- Establish the extent of acute systemic inflammation and endothelial dysfunction associated with the delivery of subgingival instrumentation for the treatment of chronic periodontitis
- Establish whether or not improved control of chronic periodontal infections results in improved endothelial function and thus the existence of a causal association between periodontitis and endothelial dysfunction.
|Periodontitis||Procedure: Intensive periodontal therapy Procedure: Community based periodontal therapy||Phase 3|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||Effects of Non-Surgical Periodontal Therapy on Endothelial Function A Randomized Controlled Clinical Trial|
- Flow mediated dilatation of the brachial artery
- Serum inflammatory and endothelial function markers
|Study Start Date:||September 2003|
|Estimated Study Completion Date:||March 2005|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00327561
|UCL Eastman Dental Institute and Hospital|
|London, United Kingdom, WC1X 8LD|
|UCL Vascular Biology Laboratory - Great Ormond Street Hospital|
|London, United Kingdom|
|Principal Investigator:||Maurizio Tonetti, DMD PhD||University College London Hospitals and University of Connecticut Health Center|