Working… Menu
Trial record 77 of 228 for:    EDN1

Relationship of Genes and Life Events to Blood Pressure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00327431
Recruitment Status : Completed
First Posted : May 18, 2006
Last Update Posted : May 22, 2008
Information provided by:
Sunnybrook Health Sciences Centre

Brief Summary:
Research suggests that blood pressure is influenced by both genetic and environmental factors. The goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. We hypothesize that the gene for endothelin-1 is associated with increased blood pressure. Further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.

Condition or disease Intervention/treatment
Hypertension Psychosocial Factors Genetic: Cheek swab samples for DNA

Layout table for study information
Study Type : Observational
Estimated Enrollment : 120 participants
Time Perspective: Prospective
Study Start Date : November 2006
Actual Study Completion Date : December 2007

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Previous participation in a study of psychosocial stressors and blood pressure (Double Exposure Study) and agreement to participate in follow-up studies

Exclusion Criteria:

  • Withdrawal of consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00327431

Layout table for location information
Canada, Ontario
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Sponsors and Collaborators
Sunnybrook Health Sciences Centre
Layout table for investigator information
Study Chair: Brian Baker, MB, ChB University of Toronto
Study Chair: Sheldon Tobe, MD Sunnybrook Health Sciences Centre

Layout table for additonal information Identifier: NCT00327431     History of Changes
Other Study ID Numbers: 1000009109
First Posted: May 18, 2006    Key Record Dates
Last Update Posted: May 22, 2008
Last Verified: May 2008
Keywords provided by Sunnybrook Health Sciences Centre:
Blood Pressure
Psychosocial Factors
Additional relevant MeSH terms:
Layout table for MeSH terms
Vascular Diseases
Cardiovascular Diseases