Relationship of Genes and Life Events to Blood Pressure

This study has been completed.
Information provided by:
Sunnybrook Health Sciences Centre Identifier:
First received: May 17, 2006
Last updated: May 21, 2008
Last verified: May 2008
Research suggests that blood pressure is influenced by both genetic and environmental factors. The goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. We hypothesize that the gene for endothelin-1 is associated with increased blood pressure. Further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.

Condition Intervention
Psychosocial Factors
Genetic: Cheek swab samples for DNA

Study Type: Observational
Study Design: Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Sunnybrook Health Sciences Centre:

Estimated Enrollment: 120
Study Start Date: November 2006
Study Completion Date: December 2007

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Previous participation in a study of psychosocial stressors and blood pressure (Double Exposure Study) and agreement to participate in follow-up studies

Exclusion Criteria:

  • Withdrawal of consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00327431

Canada, Ontario
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Sponsors and Collaborators
Sunnybrook Health Sciences Centre
Study Chair: Brian Baker, MB, ChB University of Toronto
Study Chair: Sheldon Tobe, MD Sunnybrook Health Sciences Centre
  More Information

Publications: Identifier: NCT00327431     History of Changes
Other Study ID Numbers: 1000009109 
Study First Received: May 17, 2006
Last Updated: May 21, 2008
Health Authority: Canada: Ethics Review Committee

Keywords provided by Sunnybrook Health Sciences Centre:
Blood Pressure
Psychosocial Factors processed this record on May 26, 2016