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Relationship of Genes and Life Events to Blood Pressure

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00327431
First Posted: May 18, 2006
Last Update Posted: May 22, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Sunnybrook Health Sciences Centre
  Purpose
Research suggests that blood pressure is influenced by both genetic and environmental factors. The goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. We hypothesize that the gene for endothelin-1 is associated with increased blood pressure. Further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.

Condition Intervention
Hypertension Psychosocial Factors Genetic: Cheek swab samples for DNA

Study Type: Observational
Study Design: Time Perspective: Prospective

Further study details as provided by Sunnybrook Health Sciences Centre:

Estimated Enrollment: 120
Study Start Date: November 2006
Study Completion Date: December 2007
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Previous participation in a study of psychosocial stressors and blood pressure (Double Exposure Study) and agreement to participate in follow-up studies

Exclusion Criteria:

  • Withdrawal of consent
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00327431


Locations
Canada, Ontario
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Sponsors and Collaborators
Sunnybrook Health Sciences Centre
Investigators
Study Chair: Brian Baker, MB, ChB University of Toronto
Study Chair: Sheldon Tobe, MD Sunnybrook Health Sciences Centre
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00327431     History of Changes
Other Study ID Numbers: 1000009109
First Submitted: May 17, 2006
First Posted: May 18, 2006
Last Update Posted: May 22, 2008
Last Verified: May 2008

Keywords provided by Sunnybrook Health Sciences Centre:
Hypertension
Blood Pressure
Psychosocial Factors

Additional relevant MeSH terms:
Hypertension
Vascular Diseases
Cardiovascular Diseases