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Relationship of Genes and Life Events to Blood Pressure

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ClinicalTrials.gov Identifier: NCT00327431
Recruitment Status : Completed
First Posted : May 18, 2006
Last Update Posted : May 22, 2008
Sponsor:
Information provided by:
Sunnybrook Health Sciences Centre

Brief Summary:
Research suggests that blood pressure is influenced by both genetic and environmental factors. The goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. We hypothesize that the gene for endothelin-1 is associated with increased blood pressure. Further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.

Condition or disease Intervention/treatment
Hypertension Psychosocial Factors Genetic: Cheek swab samples for DNA

Study Type : Observational
Estimated Enrollment : 120 participants
Time Perspective: Prospective
Study Start Date : November 2006
Actual Study Completion Date : December 2007




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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Previous participation in a study of psychosocial stressors and blood pressure (Double Exposure Study) and agreement to participate in follow-up studies

Exclusion Criteria:

  • Withdrawal of consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00327431


Locations
Canada, Ontario
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Sponsors and Collaborators
Sunnybrook Health Sciences Centre
Investigators
Study Chair: Brian Baker, MB, ChB University of Toronto
Study Chair: Sheldon Tobe, MD Sunnybrook Health Sciences Centre

Publications:
ClinicalTrials.gov Identifier: NCT00327431     History of Changes
Other Study ID Numbers: 1000009109
First Posted: May 18, 2006    Key Record Dates
Last Update Posted: May 22, 2008
Last Verified: May 2008

Keywords provided by Sunnybrook Health Sciences Centre:
Hypertension
Blood Pressure
Psychosocial Factors

Additional relevant MeSH terms:
Hypertension
Vascular Diseases
Cardiovascular Diseases