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Relationship of Genes and Life Events to Blood Pressure

This study has been completed.
Information provided by:
Sunnybrook Health Sciences Centre Identifier:
First received: May 17, 2006
Last updated: May 21, 2008
Last verified: May 2008
Research suggests that blood pressure is influenced by both genetic and environmental factors. The goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. We hypothesize that the gene for endothelin-1 is associated with increased blood pressure. Further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.

Condition Intervention
Hypertension Psychosocial Factors Genetic: Cheek swab samples for DNA

Study Type: Observational
Study Design: Time Perspective: Prospective

Further study details as provided by Sunnybrook Health Sciences Centre:

Estimated Enrollment: 120
Study Start Date: November 2006
Study Completion Date: December 2007

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Previous participation in a study of psychosocial stressors and blood pressure (Double Exposure Study) and agreement to participate in follow-up studies

Exclusion Criteria:

  • Withdrawal of consent
  Contacts and Locations
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Please refer to this study by its identifier: NCT00327431

Canada, Ontario
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Sponsors and Collaborators
Sunnybrook Health Sciences Centre
Study Chair: Brian Baker, MB, ChB University of Toronto
Study Chair: Sheldon Tobe, MD Sunnybrook Health Sciences Centre
  More Information

Publications: Identifier: NCT00327431     History of Changes
Other Study ID Numbers: 1000009109
Study First Received: May 17, 2006
Last Updated: May 21, 2008

Keywords provided by Sunnybrook Health Sciences Centre:
Blood Pressure
Psychosocial Factors

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases processed this record on August 22, 2017