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The Effects of a 16-Week Individualized, Intensive Strength Training Program in Patients With Rheumatoid Arthritis

This study has been completed.
Centocor, Inc.
Information provided by:
University of Arizona Identifier:
First received: May 16, 2006
Last updated: NA
Last verified: May 2006
History: No changes posted

To assess the effects of a 16-week individualized, intensive strength training program in patients with rheumatoid arthritis. Primary and secondary outcomes include: strength and body composition, function, disease activity, pain, quality of life.

We hypothesized that improvements would be seen in all of the above outcomes.

Condition Intervention
Rheumatoid Arthritis Behavioral: strength training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Official Title: The Strength Training and Remicade Study

Resource links provided by NLM:

Further study details as provided by University of Arizona:

Primary Outcome Measures:
  • Strength
  • Body Composition
  • Function
  • Pain

Secondary Outcome Measures:
  • Quality of Life
  • Disease Activity
  • Fatigue

Estimated Enrollment: 35
Study Start Date: March 2004
Estimated Study Completion Date: January 2005

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Males and females with RA
  • Over 18 years of age
  • ACR Functional Class I and II
  • Taking Remicade >4 months

Exclusion Criteria:

  • Presence of comorbid conditions contraindicated to exercise, including, but not limited to:

    1. heart disease
    2. severe osteoporosis: (if >50 years): T score < -3.0 for hip or spine excluded; T score <-2.5 for hip or spine w/o current treatment)
    3. (all potential subjects) previous non-traumatic fractures
    4. uncontrolled BP
  • BMI >40
  • Regular use of assistive walking device which would interfere with ability to lift weights
  • Currently or within the last 3 months participating in aerobic exercise > 150 minutes a week
  • Currently or within the last 3 months participating in any regular strength training activities
  • Presence of neurological impairment that directly limits ability to perform exercise
  • Participation in concurrent exercise study
  • Any reason for which the investigator deems it would not be in the patient’s best interest to continue in the study
  • Plans to move away from site within next 1 year
  Contacts and Locations
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Please refer to this study by its identifier: NCT00327275

United States, Arizona
University of Arizona
Tucson, Arizona, United States, 85721
Sponsors and Collaborators
University of Arizona
Centocor, Inc.
Principal Investigator: Hilary G Flint-Wagner, PhD, MPH Idaho State University
  More Information Identifier: NCT00327275     History of Changes
Other Study ID Numbers: 080192
Study First Received: May 16, 2006
Last Updated: May 16, 2006

Additional relevant MeSH terms:
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases processed this record on September 19, 2017