Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Effectiveness of Nigella Sativa (Kalonji) Seed in Dyslipidemia

This study has been completed.
Information provided by:
Aga Khan University Identifier:
First received: May 16, 2006
Last updated: June 30, 2015
Last verified: April 2007

This is a pilot study.

The aim of the investigators' study is to evaluate the effectiveness of nigella sativa seed in the treatment of dyslipidemia.

Dyslipidemia is a common risk factor for cardiovascular disease, the leading cause for morbidity and mortality among patients.

Nigella sativa is an easily available and acceptable remedy to treat dyslipidemia and at a low cost.

It is expected that by scientifically determining the effectiveness of this intervention it will lead to its widespread use.

This will provide a low cost alternative to treat dyslipidemia.

Condition Intervention Phase
Diabetes Mellitus
Metabolic Syndrome X
Drug: Nigella sativa seed
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Effectiveness of Nigella Sativa (Kalonji) Seed in Dyslipidemia: A Randomized Controlled Trial

Resource links provided by NLM:

Further study details as provided by Aga Khan University:

Primary Outcome Measures:
  • The primary end point for the trial is serum low-density lipoprotein (LDL) cholesterol concentration measured at six weeks after intervention. [ Time Frame: six weeks ]

Secondary Outcome Measures:
  • Serum total cholesterol concentrations measured at six weeks after intervention [ Time Frame: six weeks ]
  • Serum concentrations of high-density lipoprotein (HDL) cholesterol measured at six weeks after intervention [ Time Frame: six weeks ]
  • Serum triglyceride concentrations measured at six weeks after intervention [ Time Frame: six weeks ]
  • Serum blood sugar concentrations measured at six weeks after intervention [ Time Frame: six weeks ]
  • Blood pressure measured at six weeks after intervention [ Time Frame: six weeks ]
  • Changes in serum creatinine after six weeks intervention [ Time Frame: six weeks ]

Enrollment: 80
Study Start Date: February 2006
Study Completion Date: March 2007
Arms Assigned Interventions
Experimental: Nigella sativa seed Drug: Nigella sativa seed
No Intervention: Control

  Show Detailed Description


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Adult (18 years or older) men and women
  • Serum cholesterol > 180 mgs/dl
  • Provide Informed Consent

Exclusion Criteria:

  • Diabetes mellitus
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00327054

Aga Khan University
Karachi, Sindh, Pakistan, 74800
Sponsors and Collaborators
Aga Khan University
Principal Investigator: Waris - Qidwai Aga Khan University, Karachi
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00327054     History of Changes
Other Study ID Numbers: 05201MED(Grant Fund#1VJ)
Study First Received: May 16, 2006
Last Updated: June 30, 2015

Keywords provided by Aga Khan University:
Herbal medicine
Home remedy
Alternative medicine
Metabolic syndrome

Additional relevant MeSH terms:
Diabetes Mellitus
Metabolic Syndrome X
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Insulin Resistance
Lipid Metabolism Disorders processed this record on May 25, 2017