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Effects of Aircraft Cabin Altitude on Passenger Comfort and Discomfort

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ClinicalTrials.gov Identifier: NCT00326703
Recruitment Status : Completed
First Posted : May 17, 2006
Last Update Posted : October 17, 2006
Sponsor:
Information provided by:

Study Description
Brief Summary:

Commercial aircraft passengers are exposed to atmospheric pressures ranging from the pressure found at ground level to that encountered in the external environment at 8,000 feet. There is some evidence in the medical literature that symptoms of acute mountain sickness can result from ascent to altitudes of 6,300 to 10,000 feet by unacclimated persons during the first few days following ascent, probably due to the hypoxia that results from breathing air at the reduced ambient pressures at altitude. The logical hypothesis that follows is that exposure to 8,000 feet could cause hypoxia sufficient to adversely affect the comfort and well being of some commercial aircraft passengers on prolonged flights. There is insufficient data in the literature to validate this hypothesis.

Exercise at sea level and at altitude reduces arterial oxygen levels. The logical hypothesis that follows is that the combination of moderate exercise and exposure to altitude could cause hypoxia sufficiently severe to adversely affect the comfort and well being of some people and that the combined effect of exercise and altitude on comfort and well being is greater than the effect of exercise or altitude alone. Again, there is insufficient evidence in the literature to substantiate this possibility.

The purpose of this investigation is to test these hypotheses.


Condition or disease Intervention/treatment
Acute Mountain Sickness Procedure: Hypobaric hypoxia

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Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 500 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Official Title: Investigation to Determine the Effects of Aircraft Cabin Altitudes on Passenger Comfort and Discomfort
Study Start Date : October 2002
Estimated Study Completion Date : April 2003

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions


Outcome Measures

Primary Outcome Measures :
  1. ESQ IV factor scores measured at 2 hour intervals
  2. Oxygen Saturation measured at 2 hour intervals

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   21 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria: age 21 - 75

Exclusion Criteria:Height greater than 6'2", BMI greater than 45. Specified acute or chronic medical conditions -

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00326703


Sponsors and Collaborators
The Boeing Company
Investigators
Principal Investigator: James M Muhm, MD, MPH The Boeing Company
More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00326703     History of Changes
Other Study ID Numbers: Boeing001
First Posted: May 17, 2006    Key Record Dates
Last Update Posted: October 17, 2006
Last Verified: May 2006

Keywords provided by The Boeing Company:
hypoxia
hypobaric
altitude

Additional relevant MeSH terms:
Altitude Sickness
Respiration Disorders
Respiratory Tract Diseases