The Effect of Hyperglycaemia on Local Energy Stores in the Working Muscle in Patients With Type 1 Diabetes Mellitus
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Paired difference in the time to complete a time trial corresponding to 5 km cycling between euglycaemia and hyperglycaemia
Secondary Outcome Measures
Muscle glycogen content during exercise in the working muscle (pre test vs. post test), in euglycaemia and hyperglycaemia respectively (All following endpoints are paired differences (euglycaemia vs. hyperglycaemia) of paired differences (pre
IMCL content during exercise in the working muscle
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Ages Eligible for Study:
20 Years to 40 Years (Adult)
Sexes Eligible for Study:
Aged from 20 to 40 years
Patients with type 1 diabetes mellitus lasting for at least 5 years (C-Peptide ≤ 0.3 nmol/l in the presence of a plasma glucose level ≥ 7 mmol/L, indicating insulin dependence)
Insulin delivery by CSII (continuous subcutaneous insulin infusion) for at least 6 months
Acceptable to good metabolic control, reflected by an HbA1c 5-8%
Normal insulin sensitivity, reflected by a daily insulin requirement of 0.3-1.0 U/kg body weight