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Plasma Brain Natriuretic Peptide Levels in Pregnancy

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ClinicalTrials.gov Identifier: NCT00324402
Recruitment Status : Completed
First Posted : May 11, 2006
Last Update Posted : July 9, 2008
Sponsor:
Information provided by:
Oklahoma State University Center for Health Sciences

Brief Summary:
To evaluate the maternal blood concentrations of brain natriuretic peptide (BNP) during the second and third trimesters of a normal pregnancy. We will attempt to define a normal range for pregnancy and any outliers that may serve as markers for abnormal cardiovascular physiology.

Condition or disease
Cardiomyopathy Pregnancy

Detailed Description:
The brain natriuretic peptide (BNP) is a useful marker for volume overload, increased filling pressures and stretching of the myocardium. The current literature contains limited and unreliable information regarding normal BNP values in pregnancy. After baseline echocardiogram to detect individuals with asymptomatic structural defects, the participants will submit to 3 blood draws during the second and third trimester and at delivery to determine normal pregnancy values.

Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Plasma Brain Natriuretic Peptide Levels in Pregnancy
Study Start Date : August 2006
Actual Study Completion Date : June 2008

Group/Cohort
1
Healthy pregnant women, 18-40




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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy pregnant women, 18-40
Criteria

Inclusion Criteria:

  • women age 18 to 40
  • second trimester of pregnancy

Exclusion Criteria:

  • known cardiac or valvular disease,
  • atrial fibrillation or other arrhythmia,
  • pulmonary hypertension,
  • chronic hypertension,
  • hypertensive disorders of pregnancy,
  • morbid obesity (BMI > 40 kg/meter squared)
  • history of sleep apnea
  • multiple gestation
  • known renal dysfunction
  • medications known to affect cardiac function
  • current or past abnormal echocardiogram

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00324402


Locations
United States, Oklahoma
Oklahoma State University Center for Health Sciences
Tulsa, Oklahoma, United States, 74127
Sponsors and Collaborators
Oklahoma State University Center for Health Sciences
Investigators
Study Chair: Kimberly A Sorensen, DO Oklahoma State University Center for Health Sciences
Principal Investigator: John M Beal, DO Oklahoma State University Center for Health Sciences

Responsible Party: Dr. J. Martin Beal, assistant professor of Ob/Gyn, Oklahoma State University Center for Health Sciences
ClinicalTrials.gov Identifier: NCT00324402     History of Changes
Other Study ID Numbers: 2005008
First Posted: May 11, 2006    Key Record Dates
Last Update Posted: July 9, 2008
Last Verified: July 2008

Keywords provided by Oklahoma State University Center for Health Sciences:
brain natriuretic peptide
pregnancy
biomarker

Additional relevant MeSH terms:
Cardiomyopathies
Heart Diseases
Cardiovascular Diseases
Natriuretic Peptide, Brain
Natriuretic Agents
Physiological Effects of Drugs