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Tai-Chi-Chuan on Differentiation and Maturation of Dendritic Cells

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ClinicalTrials.gov Identifier: NCT00322959
Recruitment Status : Completed
First Posted : May 8, 2006
Last Update Posted : September 22, 2008
Sponsor:
Information provided by:

Study Description
Brief Summary:

Tai-Chi-Chuan (TCC), a branch of traditional Chinese martial arts, has been widely practiced since the 17th century. Recent studies have shown that TCC can improve cardiorespiratory function, muscle strength, humoral and cellular immunity, metabolic response and mental control.

Cultured monocytes from blood or bone marrow can be triggered to differentiate to myeloid dendritic cells (DC). DCs are specialized leukocytes for presenting antigens to quiescent, naive, and memory T cells, and they play pivotal roles in the induction of cell-mediated as well as humoral immune responses in vivo. Mature DCs have a capacity for initiating immunity or tolerance, which depends on their activation state.

In this study we will investigate the effect of TCC on DC differentiation in the peripheral blood obtained from the healthy donors who take part with and without TCC exercise. The distribution of various DC sub-populations (myeloid DC and plasmacytoid cell) will be analyzed by detecting surface marker expression.


Condition or disease
Immunity

  Show Detailed Description

Study Design

Study Type : Observational
Actual Enrollment : 20 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Effect of Tai-Chi-Chuan on Differentiation and Maturation of Human Dendritic Cells
Study Start Date : August 2004
Primary Completion Date : November 2006
Study Completion Date : November 2006
Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
TCC practitioner and Healthy subjects as controls
Criteria

Inclusion Criteria:

  • Yang TCC practitioner who keep practicing at least 3 times a week for more than 3 years
  • Healthy subjects as controls

Exclusion Criteria:

  • Who have a history of significant cardiovascular, pulmonary, and musculoskeletal diseases
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00322959


Locations
Taiwan
Department of Medical Research, Mackay Memorial Hospital
Taipei, Taiwan, 104
Sponsors and Collaborators
Mackay Memorial Hospital
Investigators
Principal Investigator: Yu-Jen Chen, MD, PhD Mackay Memorial Hospital
More Information

Publications:
Responsible Party: Yu-Jen Chen, Mackay Memorial Hospital
ClinicalTrials.gov Identifier: NCT00322959     History of Changes
Other Study ID Numbers: MMH-I-S-056
First Posted: May 8, 2006    Key Record Dates
Last Update Posted: September 22, 2008
Last Verified: September 2008

Keywords provided by Mackay Memorial Hospital:
dendritic cells
Tai-Chi-Chuan