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Intermittent Versus Continuous Renal Replacement Therapy for Acute Renal Failure

This study has been terminated.
Information provided by:
Ziekenhuis Netwerk Antwerpen (ZNA) Identifier:
First received: May 5, 2006
Last updated: October 25, 2006
Last verified: April 2005

This multicentre SHARF4 (Stuivenberg Hospital Acute Renal Failure) study aims to investigate outcome in patients with acute renal failure (ARF), stratified according to severity of disease (SHARF score) and randomised to different treatment options.

All adult patients with a serum creatinine >2 mg/dl were included. Patients were stratified according to disease severity and those in need for RRT were randomised to intermittent (IRRT) or continuous renal replacement therapy (CRRT)

Condition Intervention
Renal Insufficiency, Acute Renal Replacement Therapy Procedure: renal replacement therapy (intermittent or continuous)

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Multicentre Randomised Trial of Intermittent Versus Continuous Renal Replacement Therapy for Acute Renal Failure

Further study details as provided by Ziekenhuis Netwerk Antwerpen (ZNA):

Estimated Enrollment: 1628
Study Start Date: April 2001
Estimated Study Completion Date: March 2005
  Show Detailed Description


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • adults (>17 years)
  • having acute renal failure: serum creatinine > 2 mg/dl
  • being in need for chronic renal replacement therapy (the decision to treat conservatively or to start RRT was at the discretion of the attending physician, taking into account the rules of good clinical practice in this field)

Exclusion Criteria:

  • patients with known pre-existing chronic renal disease, defined as a serum creatinine above 1.5 mg/dl or with clearly reduced kidney size on ultrasound were excluded.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00322933

Robert Lins
Antwerp, Belgium, 2170
Sponsors and Collaborators
Ziekenhuis Netwerk Antwerpen (ZNA)
Principal Investigator: Robert L Lins, MD PhD Ziekenhuis Netwerk Antwerpen (ZNA)
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00322933     History of Changes
Other Study ID Numbers: SHARF4
Study First Received: May 5, 2006
Last Updated: October 25, 2006

Keywords provided by Ziekenhuis Netwerk Antwerpen (ZNA):
intermittent renal replacement therapy
continuous renal replacement therapy
acute renal failure
renal recovery

Additional relevant MeSH terms:
Renal Insufficiency
Acute Kidney Injury
Kidney Diseases
Urologic Diseases processed this record on August 22, 2017