We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu

Intermittent Versus Continuous Renal Replacement Therapy for Acute Renal Failure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00322933
Recruitment Status : Terminated
First Posted : May 8, 2006
Last Update Posted : October 26, 2006
Information provided by:
Ziekenhuis Netwerk Antwerpen (ZNA)

Brief Summary:

This multicentre SHARF4 (Stuivenberg Hospital Acute Renal Failure) study aims to investigate outcome in patients with acute renal failure (ARF), stratified according to severity of disease (SHARF score) and randomised to different treatment options.

All adult patients with a serum creatinine >2 mg/dl were included. Patients were stratified according to disease severity and those in need for RRT were randomised to intermittent (IRRT) or continuous renal replacement therapy (CRRT)

Condition or disease Intervention/treatment
Renal Insufficiency, Acute Renal Replacement Therapy Procedure: renal replacement therapy (intermittent or continuous)

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 1628 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Multicentre Randomised Trial of Intermittent Versus Continuous Renal Replacement Therapy for Acute Renal Failure
Study Start Date : April 2001
Estimated Study Completion Date : March 2005

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • adults (>17 years)
  • having acute renal failure: serum creatinine > 2 mg/dl
  • being in need for chronic renal replacement therapy (the decision to treat conservatively or to start RRT was at the discretion of the attending physician, taking into account the rules of good clinical practice in this field)

Exclusion Criteria:

  • patients with known pre-existing chronic renal disease, defined as a serum creatinine above 1.5 mg/dl or with clearly reduced kidney size on ultrasound were excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00322933

Robert Lins
Antwerp, Belgium, 2170
Sponsors and Collaborators
Ziekenhuis Netwerk Antwerpen (ZNA)
Principal Investigator: Robert L Lins, MD PhD Ziekenhuis Netwerk Antwerpen (ZNA)

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00322933     History of Changes
Other Study ID Numbers: SHARF4
First Posted: May 8, 2006    Key Record Dates
Last Update Posted: October 26, 2006
Last Verified: April 2005

Keywords provided by Ziekenhuis Netwerk Antwerpen (ZNA):
intermittent renal replacement therapy
continuous renal replacement therapy
acute renal failure
renal recovery

Additional relevant MeSH terms:
Renal Insufficiency
Acute Kidney Injury
Kidney Diseases
Urologic Diseases