Expanded Breast Cancer Registry and Tissue Repository
- To register patients diagnosed with breast cancer and information relevant to their diagnosis (such as stage, grade, hormone receptor status, etc), treatment (surgery, radiation, chemotherapy, hormone therapy, etc), and survivorship (QoL, etc).
- To collect relevant demographics including age, menopausal status, race/ethnicity, BMI, place of residence, behaviors (smoking, alcohol intake, etc)
- To establish a paired tumor tissue and blood sample for each relevant time-point (as defined in the full protocol), which will be stored in the Tissue Bank Shared Resource Facility for future hypothesis driven research.
|Study Type:||Observational [Patient Registry]|
|Study Design:||Observational Model: Cohort|
|Target Follow-Up Duration:||20 Years|
|Official Title:||Expanded Breast Cancer Registry and Tissue Repository|
- Identify risk factors for breast cancer [ Time Frame: 4 years ] [ Designated as safety issue: No ]Prospectively collect demographic, risk factor, diagnosis and treatment data and tissues (blood, buccal cells and tumor if appicable) for breast cancer patients seen at the UNM Cancer Center to assist in identification of unique factors that may impact patient prognosis in this population.
- Establish a centralized tissue repository [ Time Frame: 4 years ] [ Designated as safety issue: No ]Establish a centralized tissue repository (breast and related tissues) to serve as a resource for current and future scientific studies.
- Assess clinico-pathologiv variables and outcomes [ Time Frame: 10 years ] [ Designated as safety issue: No ]Utilize the Extended Breast Cancer Repository clinical database to determine the relationship between clinico-pathologic variables and patient outcomes.
Biospecimen Retention: Samples With DNA
Sample of tumor, buccal cells and blood collected at the time of study enrollment.
|Study Start Date:||February 2006|
|Estimated Study Completion Date:||October 2016|
|Estimated Primary Completion Date:||October 2015 (Final data collection date for primary outcome measure)|
Institutions and/or physicians are required to report each new diagnosis of breast cancer to the New Mexico Tumor Registry (NMTR). The NMTR is a valuable database that provides information on breast cancer, including trends in incidence and survival. However, relevant information on breast cancer prognosis and treatment is either not routinely collected or not readily available to the NMTR. We propose to establish an Expanded Breast Cancer Registry and Tissue Repository at this institution that could serve as an infrastructure for collection of this information. Furthermore, a tissue bank will be established for collection of paired tissue (tumor, buccal cells and blood sample) from patients diagnosed with breast cancer who consent to providing excess/extra tissue and additional blood for the Tissue Repository. This tissue bank will serve as a repository from which researchers can access tissue samples to conduct laboratory-based studies of genetic determinants of breast cancer risks, prognosis and survival in women with breast cancer seen in this institution.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00322894
|United States, New Mexico|
|University of New Mexico Cancer Center|
|Albuquerque, New Mexico, United States, 87131|
|Principal Investigator:||Melanie Royce, MD||University of New Mexico Cancer Center|