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A Retrospective Study of the Role of Thiazolidinediones to Reduce the Incidence of Atrial Arrhythmias

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ClinicalTrials.gov Identifier: NCT00321204
Recruitment Status : Terminated (Terminated: We are no longer recruiting.)
First Posted : May 3, 2006
Last Update Posted : April 23, 2014
Sponsor:
Information provided by (Responsible Party):
Samuel C. Dudley, Jr., Emory University

Brief Summary:
It is well known that abnormal heart beats from the top parts of the heart, atrial fibrillation (AF) and atrial flutter (Aflut), occur frequently after most types of cardiac surgeries. Postoperative AF and Aflut are associated with significant morbidity, longer hospital stay, and higher related costs. Currently therapies are marginally effective at preventing this abnormal heart beat. The incidence of abnormal heart beats after cardiac surgery seems to be a function of the amount of inflammation and oxidative stress induced. Our group and others have shown that atrial abnormal heart beats are associated with increased oxidative stress. Thiazolidinediones (TZDs) are medications used to treat diabetes. Beside their glucose lowering effects, TZDs are shown to exhibit anti-inflammatory and antioxidant properties. Therefore, we propose to retrospectively analyze the effect of pre-operative TZDs on the incidence of post-operative AF or Aflut. This study will involve retrospective chart reviews without further patient contact of all patients having undergone cardiac surgery in Emory University Hospital, Crawford Long Hospital, or the VA Medical Center from 2000 to 2005. This study is preparatory to a funding proposal for a prospective trial.

Condition or disease Intervention/treatment
Atrial Fibrillation Procedure: TZD reducing the incidence of atrial arrhythmias

  Show Detailed Description

Study Type : Observational
Enrollment : 600 participants
Official Title: A Retrospective Study of the Role of Thiazolidinediones to Reduce the Incidence of Atrial Arrhythmias in Patients After Cardiac Surgery
Study Start Date : December 2005
Actual Primary Completion Date : February 2007
Actual Study Completion Date : February 2007

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

All patient who underwent elective cardiac Surgery in the Emory University Hospital, Crawford Long Hospital, or the Va Medical Center between 2000-2005.-

Exclusion Criteria:


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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00321204


Locations
United States, Georgia
Emory University Hospital
Atlanta, Georgia, United States, 30322
Emory Crawford Long Hospital
Atlanta, Georgia, United States, 30365
Veteran Administration Medical Center
Decatur, Georgia, United States, 30033
Sponsors and Collaborators
Emory University
Investigators
Principal Investigator: Samuel C. Dudley, Jr., MD, PhD Veteran Administration Medical Center/Emory University

Responsible Party: Samuel C. Dudley, Jr., Principal Investigator, Emory University
ClinicalTrials.gov Identifier: NCT00321204     History of Changes
Other Study ID Numbers: IRB00002175
1308-2005 ( Other Identifier: Other )
First Posted: May 3, 2006    Key Record Dates
Last Update Posted: April 23, 2014
Last Verified: April 2014

Keywords provided by Samuel C. Dudley, Jr., Emory University:
Atrial Fibrillation
Atrial Flutter
Cardiac Surgery
Thiazolidinediones

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
2,4-thiazolidinedione
Hypoglycemic Agents
Physiological Effects of Drugs