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A Retrospective Study of the Role of Thiazolidinediones to Reduce the Incidence of Atrial Arrhythmias

This study has been terminated.
(Terminated: We are no longer recruiting.)
Information provided by (Responsible Party):
Samuel C. Dudley, Jr., Emory University Identifier:
First received: May 1, 2006
Last updated: April 21, 2014
Last verified: April 2014
It is well known that abnormal heart beats from the top parts of the heart, atrial fibrillation (AF) and atrial flutter (Aflut), occur frequently after most types of cardiac surgeries. Postoperative AF and Aflut are associated with significant morbidity, longer hospital stay, and higher related costs. Currently therapies are marginally effective at preventing this abnormal heart beat. The incidence of abnormal heart beats after cardiac surgery seems to be a function of the amount of inflammation and oxidative stress induced. Our group and others have shown that atrial abnormal heart beats are associated with increased oxidative stress. Thiazolidinediones (TZDs) are medications used to treat diabetes. Beside their glucose lowering effects, TZDs are shown to exhibit anti-inflammatory and antioxidant properties. Therefore, we propose to retrospectively analyze the effect of pre-operative TZDs on the incidence of post-operative AF or Aflut. This study will involve retrospective chart reviews without further patient contact of all patients having undergone cardiac surgery in Emory University Hospital, Crawford Long Hospital, or the VA Medical Center from 2000 to 2005. This study is preparatory to a funding proposal for a prospective trial.

Condition Intervention Phase
Atrial Fibrillation
Procedure: TZD reducing the incidence of atrial arrhythmias
Phase 2

Study Type: Observational
Official Title: A Retrospective Study of the Role of Thiazolidinediones to Reduce the Incidence of Atrial Arrhythmias in Patients After Cardiac Surgery

Resource links provided by NLM:

Further study details as provided by Emory University:

Estimated Enrollment: 600
Study Start Date: December 2005
Study Completion Date: February 2007
Primary Completion Date: February 2007 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

All patient who underwent elective cardiac Surgery in the Emory University Hospital, Crawford Long Hospital, or the Va Medical Center between 2000-2005.-

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT00321204

United States, Georgia
Emory University Hospital
Atlanta, Georgia, United States, 30322
Emory Crawford Long Hospital
Atlanta, Georgia, United States, 30365
Veteran Administration Medical Center
Decatur, Georgia, United States, 30033
Sponsors and Collaborators
Emory University
Principal Investigator: Samuel C. Dudley, Jr., MD, PhD Veteran Administration Medical Center/Emory University
  More Information

Responsible Party: Samuel C. Dudley, Jr., Principal Investigator, Emory University Identifier: NCT00321204     History of Changes
Other Study ID Numbers: IRB00002175
1308-2005 ( Other Identifier: Other )
Study First Received: May 1, 2006
Last Updated: April 21, 2014

Keywords provided by Emory University:
Atrial Fibrillation
Atrial Flutter
Cardiac Surgery

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on April 26, 2017