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Desipramine for Improving Cellular Signaling and Decreasing Symptoms of Major Depression

This study has been completed.
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
JohnMooney, Harvard Medical School Identifier:
First received: April 28, 2006
Last updated: August 17, 2015
Last verified: August 2015
This study will determine the effectiveness of desipramine in improving cellular signaling, and thereby decreasing symptoms of depression in people with major depressive disorder (MDD).

Condition Intervention Phase
Depression Drug: Desipramine Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Psychopharmacology of Biogenic Amines in Depression

Resource links provided by NLM:

Further study details as provided by JohnMooney, Harvard Medical School:

Primary Outcome Measures:
  • Measured at Weeks 1, 4, and 6: Catecholamine metabolism and blood cell adenylate cyclase activity
  • Score on the 21-item Hamilton Depression Rating Scale

Estimated Enrollment: 43
Study Start Date: August 1990
Estimated Study Completion Date: July 1993
Detailed Description:

MDD is a serious mental illness that can interfere with a person's ability to eat, sleep, work, and enjoy activities that were once pleasurable. It is characterized by several symptoms, including as the following: persistent sad, anxious, or "empty" mood; feelings of hopelessness or pessimism; and feelings of guilt, worthlessness, or helplessness. The receptor-G protein-adenylate cyclase enzyme complex (AC enzyme complex) is a major cell signaling system in the brain, blood, and other tissues in the body. Changes in this signaling system among blood cells have been observed in people with major depressive disorder. Research has shown that treatment with the benzodiazepine alprazolam corrects the signaling problem, and thereby improves symptoms of MDD. This study will determine whether impairments in the AC enzyme complex exist among depressed individuals. This study will also evaluate the effectiveness of desipramine, an antidepressant, in improving blood cell signaling, and thereby decreasing symptoms of depression in people with major depressive disorder.

Both healthy and depressed participants will be recruited for this study. All depressed participants in this study will first be assessed for depression severity using the Hamilton Depression Rating Scale. If eligible for the study, participants will be examined to determine AC enzyme complex functioning in both platelets and mononuclear leukocytes. A cohort of the depressed participants will be treated with desipramine. They will be examined to determine the drug's effect on AC enzyme complex functioning, as well as its effect on MDD symptoms, at Weeks 1, 4, and 6.


Ages Eligible for Study:   19 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Clinical diagnosis of MDD (as defined by SCID [DSM III-R] and a score of at least 15 on the 21-item Hamilton Depression Scale)
  • Able to swallow tablets, give urine and blood samples, and participate in periodic evaluations during the study
  • Healthy volunteers show no current Axis I or Axis II disorders and score less than 8 on the Hamilton Depression Scale

Exclusion Criteria:

  • Use of any of the following medications within the 2 weeks prior to study entry: psychoactive medication; aspirin; or nonsteroidal anti-inflammatory agents
  • Any alcohol or drug abuse within the 6 months prior to study entry
  • Any major medical disorder
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Please refer to this study by its identifier: NCT00320632

United States, Massachusetts
Massachusetts Mental Health Center
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
Harvard Medical School
National Institute of Mental Health (NIMH)
Principal Investigator: Joseph J. Schildkraut, MD Department of Psychiatry, Harvard Medical School
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: JohnMooney, Principal Investigator, Harvard Medical School Identifier: NCT00320632     History of Changes
Other Study ID Numbers: R01MH015413 ( U.S. NIH Grant/Contract )
Study First Received: April 28, 2006
Last Updated: August 17, 2015

Keywords provided by JohnMooney, Harvard Medical School:
Major Depressive Disorder

Additional relevant MeSH terms:
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders
Antidepressive Agents, Tricyclic
Antidepressive Agents
Psychotropic Drugs
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Adrenergic Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Adrenergic Agents
Neurotransmitter Agents
Physiological Effects of Drugs processed this record on August 23, 2017