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The Partners Genetics Collaborative Study of Schizophrenia
This study is ongoing, but not recruiting participants.
Sponsor:
Massachusetts General Hospital
Collaborator:
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Daphne Holt, Massachusetts General Hospital
ClinicalTrials.gov Identifier:
NCT00319904
First received: April 27, 2006
Last updated: March 16, 2016
Last verified: March 2016
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Purpose
We will collect DNA from 500 rigorously diagnosed patients with schizophrenia to allow us in the future to examine phenotypic subtypes in relation to genetic variants. Phenotypes will include subgroups based on clinical symptoms, medication response, or other biological markers including neuroimaging or pharmacologic challenges.
| Condition |
|---|
| Schizophrenia |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | The Partners Genetics Collaborative Study of Schizophrenia |
Resource links provided by NLM:
Genetics Home Reference related topics:
schizophrenia
MedlinePlus related topics:
Schizophrenia
U.S. FDA Resources
Further study details as provided by Daphne Holt, Massachusetts General Hospital:
Primary Outcome Measures:
- phenotypic subtypes in relation to genetic variants [ Time Frame: Baseline ]We will collect DNA from 500 patients with schizophrenia to examine phenotypic subtypes in relation to genetic variants. Phenotypes will include subgroups based on clinical symptoms, medication response, or other biological markers including neuroimaging or pharmacologic challenges.
Biospecimen Retention: Samples With DNA
DNA is extracted and stored for future anaysis of genes that may be associated with schizophrenia
| Estimated Enrollment: | 500 |
| Study Start Date: | March 2001 |
| Estimated Study Completion Date: | October 2016 |
| Estimated Primary Completion Date: | October 2016 (Final data collection date for primary outcome measure) |
Show Detailed Description
Eligibility| Ages Eligible for Study: | 18 Years to 70 Years (Adult, Senior) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Study Population
Adults with Schizophrenia
Criteria
Inclusion Criteria:
Schizophrenia, any subtype Ages 18-70 years Males or females English speaking Ability to complete symptom rating scales and cognitive tests Ability to provide informed consent
Exclusion Criteria:
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00319904
Please refer to this study by its ClinicalTrials.gov identifier: NCT00319904
Locations
| United States, Massachusetts | |
| Freedom Trail Clinic | |
| Boston, Massachusetts, United States, 02114 | |
Sponsors and Collaborators
Massachusetts General Hospital
National Institute of Mental Health (NIMH)
Investigators
| Principal Investigator: | Daphne J Holt, M.D., PhD | Massachusetts General Hospital |
More Information
Publications:
| Responsible Party: | Daphne Holt, Associate Professor of Psychiatry, Massachusetts General Hospital |
| ClinicalTrials.gov Identifier: | NCT00319904 History of Changes |
| Other Study ID Numbers: |
2001-P-000560 |
| Study First Received: | April 27, 2006 |
| Last Updated: | March 16, 2016 |
Keywords provided by Daphne Holt, Massachusetts General Hospital:
|
Schizophrenia DNA |
Additional relevant MeSH terms:
|
Schizophrenia Schizophrenia Spectrum and Other Psychotic Disorders Mental Disorders |
ClinicalTrials.gov processed this record on September 21, 2017