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EEG Studies of Sensory Processing in Autistic Children

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2010 by Massachusetts General Hospital.
Recruitment status was:  Recruiting
CURE Foundation
The Commonwealth Fund
National Alliance for Autism Research
Nancy Lurie Marks Family Foundation
Information provided by:
Massachusetts General Hospital Identifier:
First received: April 27, 2006
Last updated: May 3, 2010
Last verified: May 2010
This study uses EEG to study brain waves at rest and in response to specific auditory and visual sensory stimuli in autistic children. We hypothesize that, compared to same age peers, autistics will show abnormalities in their electrophysiologic processing of sounds (tones and phonemes)and visual stimuli (flashes of light)and that these abnormalities will be able to separate autistics not only from typical children but also into clinical subgroups with specific biological/electrophysiological characteristics. We hope to find biological measures which will prove diagnostic of autism in very young children and which can be used in the measurement of treatment outcome in future intervention trials.

Condition Phase
Phase 1

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Electrophysiologic Indicators of Gating and Timing Abnormalities in Autism

Further study details as provided by Massachusetts General Hospital:

Primary Outcome Measures:
  • EEG and ERP abnormalities [ Time Frame: 2 years ]

Secondary Outcome Measures:
  • Characteristic and severity of autistic behaviors [ Time Frame: 2 years ]

Estimated Enrollment: 130
Study Start Date: February 2006
Estimated Study Completion Date: March 2011
Estimated Primary Completion Date: March 2011 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   3 Months to 8 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
autistic children meeting criteria for autism based on ADOS and ADI and clinical DSM IV or their siblings between the ages of 3 months to 13 years.

Inclusion Criteria:

autistic children or their younger siblings between the ages of 3 months to 8 year

Controls: typically developing children 3mo to 8 years without known language or social disorder and not related to child with autism

Exclusion Criteria: progressive encephalopathy, treatment with multiple antiepileptic drugs, known genetic diagnosis.

  Contacts and Locations
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Please refer to this study by its identifier: NCT00319722

Contact: Alyssa Orinstein 617-966-9766

United States, Massachusetts
MGH LADDERS Clinic Recruiting
Lexington, Massachusetts, United States, 02421
Contact: Katherine M. Martien, M.D.    781-860-1720   
Principal Investigator: Katherine M. Martien, M.D.         
Sponsors and Collaborators
Massachusetts General Hospital
CURE Foundation
The Commonwealth Fund
National Alliance for Autism Research
Nancy Lurie Marks Family Foundation
Principal Investigator: Katherine M. Martien, M.D. Massachusetts General Hospital
Principal Investigator: Martha Herbert, M.D. Massachusetts General Hospital
  More Information

Responsible Party: Katherine M. Martien, M.D., Principal Investigator, Massachusetts General Hospital Identifier: NCT00319722     History of Changes
Other Study ID Numbers: 2005-P-000868/3
Study First Received: April 27, 2006
Last Updated: May 3, 2010

Keywords provided by Massachusetts General Hospital:
pervasive developmental disorder
evoked potentials

Additional relevant MeSH terms:
Autistic Disorder
Child Development Disorders, Pervasive
Neurodevelopmental Disorders
Mental Disorders processed this record on May 25, 2017