Long-Term Study of Living Kidney Donors

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00319527
Recruitment Status : Completed
First Posted : April 27, 2006
Last Update Posted : July 7, 2009
National Kidney Foundation
Information provided by:
Lawson Health Research Institute

Brief Summary:
Kidney transplantation, is the preferred treatment option of end stage renal disease. Compared to dialysis, patients who receive kidneys have a 70% reduction in death, a dramatically improved quality of life and cost the health care system considerably less. As a result, there are over 3000 Canadians on the waiting list for a kidney. In order to meet the shortage of cadaveric kidneys, the rates of living kidney donation have nearly doubled over the last 10 years. Yet despite its advantages for the recipient, living kidney donation remains a complex ethical, moral, and medical issue. The premise for accepting living donors is that the "minimal" risk of short and long-term medical harm realized by the donor is outweighed by the definite advantages to the recipient and potential psychosocial benefits of the altruistic gift to the donor. The only benefit for the living donor is psychological - donors experience increased self-esteem, feelings of well-being, and improved health related quality of life with their altruistic act of assuming medical risk to help another. The short-term consequences of living donation are well established. On the other hand the long-term consequences of living kidney donation are far less certain. The main medical concerns of living kidney donation include an increased risk of hypertension, proteinuria, and low glomerular filtration rate (GFR- a measure of the filtering capacity of the kidney). Estimates of these outcomes are variable, inconsistent, and uncertain in the literature. This study is designed to quantify the long-term medical and psychosocial implications of living kidney donation.

Condition or disease
Kidney Diseases

Study Type : Observational
Actual Enrollment : 311 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Long-Term Medical and Psychological Implications of Becoming a Living Kidney Donor: A Historical Matched Cohort Study
Study Start Date : May 2004
Actual Primary Completion Date : March 2008
Actual Study Completion Date : March 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Kidney Diseases

Living Kidney Donors with controls who have not donated a kidney or had certain criteria at the time of the donor's donation (i.e. no hypertension, no kidney disease, etc.).

Biospecimen Retention:   Samples Without DNA
Serum and urine samples

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Living Kidney Donors

Inclusion Criteria:

  • Age greater than 18 years old
  • Living kidney transplant occurred between 1970 and 2006
  • no history of hypertension, kidney disease or proteinuria prior to donation

Exclusion Criteria:

  • a medical condition (such as cardiovascular disease, pulmonary disease, or active cancer) which makes one ineligible to be a donor. Blood group and immunological incompatibility (such as positive cross-match, poor HLA matches) are not reasons for exclusion.
  • The eligible non-donor subsequently went on to donate a kidney
  • Either the donor or the eligible non-donor are unable to give informed consent
  • The living donor or eligible non-donor is currently pregnant

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00319527

Australia, Western Australia
Sir Charles Gairdner Hospital
Nedlands, Western Australia, Australia, 6009
Canada, Alberta
University of Alberta
Edmonton, Alberta, Canada, T6G 2G3
Canada, British Columbia
St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Canada, Nova Scotia
Dalhousie University
Halifax, Nova Scotia, Canada, B3H 1V8
Canada, Ontario
St. Joseph's Hospital
Hamilton, Ontario, Canada, L8N 4A6
London Health Sciences Centre
London, Ontario, Canada, N5A 4G5
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H 7W9
St Michaels Hospital
Toronto, Ontario, Canada
University Health Network
Toronto, Ontario, Canada
United Kingdom
Western Infirmary
Glasgow, United Kingdom
Sponsors and Collaborators
Lawson Health Research Institute
National Kidney Foundation
Principal Investigator: Amit X Garg, MD Lawson Health Research Institute

Responsible Party: Dr. Amit Garg, Lawson Health Research Institute Identifier: NCT00319527     History of Changes
Other Study ID Numbers: R-04-078
LKD Retrospective Study
First Posted: April 27, 2006    Key Record Dates
Last Update Posted: July 7, 2009
Last Verified: July 2009

Keywords provided by Lawson Health Research Institute:
long term outcome
living kidney donor

Additional relevant MeSH terms:
Kidney Diseases
Urologic Diseases