Prognosis Factors Associated With Convulsive Status Epilepticus in Adults

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00318578
Recruitment Status : Completed
First Posted : April 27, 2006
Last Update Posted : August 15, 2007
Information provided by:
Versailles Hospital

Brief Summary:
The aim of the study is to evaluate, prospectively, prognosis factors associated with convulsive status epilepticus (CSE) in adults hospitalized in intensive care units.

Condition or disease
Status Epilepticus

Detailed Description:

Status epilepticus is a neurologic and medical emergency associated with high mortality and morbidity rates. According to the operational definition Convulsive Status Epilepticus (CSE) is defined as a single clinical seizure lasting more than 10 min, or two or more repeated seizures over a period of more than 10 minutes without intervening recovery of consciousness.

There are a few to date in literature reporting prognosis factors associated with this condition and, at this time, there are no published data considering an operational definition of CSE.

In a retrospective study considering an operational definition we identified a seizure duration of 15 min associated with poor outcome (not yet published).

The principal goal of this study is to evaluate factors associated with outcome in CSE, in particular seizure duration of more than 15 minutes.

The secondary goals are to evaluate the epidemiology and management at every stage of CSE thus redefined.

Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Defined Population
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Prognosis Factors Associated With Convulsive Status Epilepticus in Adults: A Multicenter Cohort Study
Study Start Date : March 2005
Study Completion Date : January 2007

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • More than 18 years old
  • Convulsive status epilepticus according to operational definition as any seizure lasting for 10 minutes or longer, or two or more intermittent seizures lasting for greater than 10 minutes from which the patient did not regain consciousness.
  • Beginning of seizure less than 12 hours before intensive care unit admission
  • Convulsive status epilepticus occurring during intensive care unit stay

Exclusion Criteria:

  • Less than 18 years old
  • Patients that seized up to 9 minutes
  • Beginning of seizure more than 12 hours before intensive care unit admission

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00318578

Centre Hospitalier d'Abbeville
Abbeville, France, 80100
Centre Hospitalier d'Annonay
Annonay, France, 07103
Centre Hospitalier Victor Dupouy
Argenteuil, France, 95100
Centre Hospitalier Robert Ballanger
Aulnay Sous Bois, France, 93
Centre Hospitalier Rene Dubos
Cergy Pontoise, France, 95303
Centre Hospitalier de Chartres
Chartres, France, 28
Centre Hospitalier de Châlons-en-Champagne
Châlons-en-Champagne, France, 51000
Centre Hospitalier Universitaire Antoine Beclere
Clamart, France, 92140
Hopital Gabriel Montpied
Clermont Ferrand, France, 63000
Centre Hospitalier de Compiegne
Compiegne, France, 60200
Centre Hospitalier Universitaire Henri Mondor
Creteil, France, 94000
Centre Hospitalier de Dourdan
Dourdan, France, 91410
Centre Hospitalier de Dreux
Dreux, France, 28102
Centre Hospitalier Universitaire de Grenoble
Grenoble, France, 38
Centre Hospitalier de Versailles
Le Chesnay, France, 78150
Centre Hospitalier Universitaire La Timone
Marseille, France, 13385
Centre Hospitalier Sambre Avesnois
Maubeuge, France, 59607
Centre Hospitalier de Meaux
Meaux, France, 77107
Centre Hospitalier Universitaire de Nancy
Nancy, France, 54035
Centre Hospitalier Pierre Bérégovoy
Nevers, France, 58000
Centre Hôspitalier ARCHET
Nice, France, 06202
Centre Hospitalier Georges Renon
Niort, France, 79021
Centre Hospitalier Universitaire d'Orléans
Orleans, France, 45067
Centre Hospitalier Universitaire Cochin
Paris, France, 75000
Centre Hospitalier Universitaire Lariboisiere
Paris, France, 75000
Centre Hospitalier Bichat Claude Bernard
Paris, France, 75
Fondation Hopital Saint Joseph
Paris, France, 75
Centre Hospitalier Francois Mitterrand
PAU, France, 64046
Clinique Mutualiste de Pessas
Pessac, France, 33600
Centre Hospitalier Universitaire de Poitiers
Poitiers, France
Centre Hospitalier de Roanne
Roanne, France, 42328
Centre Hospitalier de Rodez
Rodez, France, 12
Centre Hospitalier Mémorail France Etats Unis Saint Lo
Saint Lo, France, 50000
Centre Hospitalier Foch
Suresnes, France, 92151
Sponsors and Collaborators
Versailles Hospital
Principal Investigator: Stephane LEGRIEL, MD Centre hospitalier de versailles
Principal Investigator: Bruno MOURVILLIER, MD Centre Hospitalier Bichat Claude Bernard Identifier: NCT00318578     History of Changes
Other Study ID Numbers: LEGRIEL stephane
First Posted: April 27, 2006    Key Record Dates
Last Update Posted: August 15, 2007
Last Verified: August 2007

Keywords provided by Versailles Hospital:
convulsive status epilepticus
prognosis factors
seizure duration
intensive care unit

Additional relevant MeSH terms:
Status Epilepticus
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases