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Oxaliplatin/CPT-11 for Extensive Stage Small Cell Lung Cancer

This study has been terminated.
Information provided by:
Swedish Medical Center Identifier:
First received: April 18, 2006
Last updated: April 4, 2007
Last verified: April 2007
The purpose of this study is to determine the safety and effectiveness of the combination of oxaliplatin and irinotecan (CPT-11) in patients with previously untreated, advanced small cell lung cancer.

Condition Intervention Phase
Small Cell Lung Cancer Drug: Irinotecan (CPT-11) Drug: Oxaliplatin (Eloxatin) Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase II Study of Oxaliplatin and CPT-11 as First Line Treatment for Extensive Stage Small Cell Lung Cancer

Resource links provided by NLM:

Further study details as provided by Swedish Medical Center:

Estimated Enrollment: 24
Study Start Date: February 2005
Study Completion Date: January 2007

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Previously untreated extensive small cell lung cancer
  • No prior chemotherapy
  • No prior radiotherapy except for the treatment of brain metastases

Exclusion Criteria:

  • Prior treatment for extensive stage small cell lung cancer
  • Known hypersensitivity to any of the components of oxaliplatin or CPT-11
  • Greater than grade 2 peripheral neuropathy
  • Known HIV or Hepatitis B or C (active, previously treated or both)
  Contacts and Locations
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Please refer to this study by its identifier: NCT00316433

United States, Washington
Swedish Medical Center Cancer Institute
Seattle, Washington, United States, 98104
Sponsors and Collaborators
Swedish Medical Center
Principal Investigator: Howard (Jack) West, MD Swedish Medical Center Cancer Institute
  More Information Identifier: NCT00316433     History of Changes
Other Study ID Numbers: OX-03-099
Study First Received: April 18, 2006
Last Updated: April 4, 2007

Additional relevant MeSH terms:
Lung Neoplasms
Small Cell Lung Carcinoma
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms
Antineoplastic Agents
Antineoplastic Agents, Phytogenic
Topoisomerase I Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action processed this record on September 21, 2017