Cognitive Behavioral Therapy Plus Motivational Interviewing for Treatment of Obsessive-Compulsive Disorder
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|ClinicalTrials.gov Identifier: NCT00316316|
Recruitment Status : Completed
First Posted : April 20, 2006
Last Update Posted : March 16, 2012
|Condition or disease||Intervention/treatment||Phase|
|Obsessive-Compulsive Disorder||Behavioral: Motivational interviewing plus exposure and response prevention (MI plus EX/RP) Behavioral: Exposure and response prevention (EX/RP)||Phase 1|
Obsessive Compulsive Disorder (OCD) is a chronic and debilitating anxiety disorder. People with OCD often experience recurrent unwanted thoughts, or obsessions. Some examples of obsessions include the following: repetitive fears of causing harm or being harmed; fears of contamination and illness; fears of making mistakes; intrusive distressing sexual or religious imagery; and fears of losing things. In an effort to relieve anxiety about these obsessions, people with OCD develop repetitive behaviors called compulsions. Some examples of compulsions include the following: repetitive washing and cleaning; excessive checking; excessive ordering and arranging; and extreme hoarding and saving. These thoughts and behaviors interfere with everyday life to a great extent. Cognitive behavior therapy (CBT) with exposure and ritual prevention (EX/RP) is a standard treatment for OCD. EX/RP involves both imaginary and real exposure to situations or settings that may stimulate OCD behavior, and it requires that patients refrain from ritualizing. Motivational interviewing (MI) may help to enhance an individual's motivation to change by exploring and resolving ambivalence. This study will determine the effectiveness of adding MI to CBT that consists of EX/RP in improving treatment outcome in people with OCD.
Participants in this single-blind study will be randomly assigned to receive either standard CBT with EX/RP or CBT with EX/RP plus MI. All participants will report to the study site twice weekly for both therapy and assessments for a total of 2 months. Assessments will include interviews and self-rating forms. No medication will be administered during this study. However, participants will continue on any medication that they are taking at the time of study entry. All participants will be assessed for outcomes upon study completion. Participants who respond to therapy will be assessed again 6 months following study completion.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||Cognitive Behavioral Therapy Plus Motivational Interviewing for Obsessive Compulsive Disorder|
|Study Start Date :||March 2006|
|Actual Primary Completion Date :||March 2010|
|Actual Study Completion Date :||March 2010|
Active Comparator: 1
Participants will receive motivational interviewing plus exposure and response prevention
Behavioral: Motivational interviewing plus exposure and response prevention (MI plus EX/RP)
Participants will receive 18 sessions of MI plus EX/RP.
Other Name: MI plus EX/RP
Active Comparator: 2
Participants will receive exposure and response prevention only
Behavioral: Exposure and response prevention (EX/RP)
Participants will receive 18 sessions of EX/RP.
Other Name: EX/RP
- Obsessive-compulsive symptoms [ Time Frame: Measured at Months 2 and 8 ]
- Adherence, depression, insight, and quality of life [ Time Frame: Measured at Months 2 and 8 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00316316
|United States, New York|
|New York State Psychiatric Institute|
|New York, New York, United States, 10032|
|Principal Investigator:||Helen Blair Simpson, MD, PhD||New York State Psychiatric Institute|