Development of a New Method for Steady-State Measurement of NO Lung Diffusing Capacity in Healthy Subjects

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2007 by University Hospital Tuebingen.
Recruitment status was  Recruiting
Information provided by:
University Hospital Tuebingen Identifier:
First received: April 17, 2006
Last updated: June 13, 2007
Last verified: May 2007
Using a rapidly responding nitric oxide analyzer in a new developed modular lung-function-setup we are going to measure steady-state NO diffusing capacity in 107 healthy subjects (age 6-45 years). The results will be compared to those measured by using carbon monoxide single-breath estimates. We like to show that the new method is sufficient to measure exactly lung diffusion capacity in this collective.

Condition Intervention Phase
Pulmonary Diffusing Capacity
Drug: Nitric oxide, Carbon monoxide, Helium
Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Development of a New Method for Steady-State Measurement of NO Lung Diffusing Capacity in Healthy Subjects

Resource links provided by NLM:

Further study details as provided by University Hospital Tuebingen:

Primary Outcome Measures:
  • TLNOss
  • TLCOsb

Secondary Outcome Measures:
  • Breathing frequency
  • tidal volume
  • functional residual capacity
  • airway resistance
  • lung clearance index
  • forced expiratory volume in one second
  • vital capacity
  • total lung capacity

Estimated Enrollment: 107
Study Start Date: July 2006
Estimated Study Completion Date: September 2007

Ages Eligible for Study:   6 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy volunteers
  • Lung function testing possible
  • Written consent

Exclusion Criteria:

  • Pulmonary, neuromuscular, cardiovascular, endocrinological illness
  • Pregnancy
  • Abuse of nicotine, alcohol, drugs during the last two years
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Please refer to this study by its identifier: NCT00315965

Contact: Tobias Pantalitschka, MD +49 70712984711

University children´s hospital Recruiting
Tuebingen, Germany, 72076
Contact: Tobias Pantalitschka, MD    +49 7071 2984711   
Principal Investigator: Tobias Pantalitschka, MD         
Sponsors and Collaborators
University Hospital Tuebingen
Principal Investigator: Tobias Pantalitschka, MD University Hospital Tuebingen, Germany
  More Information Identifier: NCT00315965     History of Changes
Other Study ID Numbers: ESNOD-01 
Study First Received: April 17, 2006
Last Updated: June 13, 2007
Health Authority: Germany: Federal Institute for Drugs and Medical Devices

Keywords provided by University Hospital Tuebingen:
Membrane diffusing capacity
Alveolar capillary gas diffusion
Transfer factor
Nitric oxide diffusion

Additional relevant MeSH terms:
Carbon Monoxide
Nitric Oxide
Anti-Asthmatic Agents
Autonomic Agents
Bronchodilator Agents
Cardiovascular Agents
Endothelium-Dependent Relaxing Factors
Free Radical Scavengers
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Protective Agents
Respiratory System Agents
Therapeutic Uses
Vasodilator Agents processed this record on May 04, 2016