Prophylactic Effect of Memantine in Chronic Tension-Type Headache

This study has been completed.
Information provided by:
Danish Headache Center Identifier:
First received: April 18, 2006
Last updated: February 19, 2009
Last verified: February 2009
The purpose of this study is to test whether memantine has a prophylactic effect on chronic tension-type headaches.

Condition Intervention Phase
Tension-Type Headache
Drug: memantine
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Prophylactic Effect of Memantine in Chronic Tension-Type Headache

Resource links provided by NLM:

Further study details as provided by Danish Headache Center:

Primary Outcome Measures:
  • Headache duration
  • Headache intensity

Secondary Outcome Measures:
  • Headache frequency
  • The use of simple analgesics
  • Side effects

Estimated Enrollment: 40
Study Start Date: May 2006
Study Completion Date: June 2007
Primary Completion Date: June 2007 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Chronic tension-type headache
  • Normal urine pH

Exclusion Criteria:

  • More than 1 migraine attack/month
  • Other major illnesses
  • Overuse of medicine/alcohol
  • Women not using AC
  • Pregnant/breast-feeding women
  • Allergy to memantine
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00315666

Danish Headaches Center
Glostrup, Denmark, DK-2600
Sponsors and Collaborators
Danish Headache Center
Principal Investigator: Lars Bendtsen, MD, PhD Danish Headaches Center, Dept. of Neurology, KAS Glostrup, DK-2600 Glostrup
  More Information Identifier: NCT00315666     History of Changes
Other Study ID Numbers: 2006-000060-82  KA-20060021 
Study First Received: April 18, 2006
Last Updated: February 19, 2009
Health Authority: Denmark: Danish Medicines Agency

Keywords provided by Danish Headache Center:
Chronic tension-type headache

Additional relevant MeSH terms:
Tension-Type Headache
Brain Diseases
Central Nervous System Diseases
Headache Disorders
Headache Disorders, Primary
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Anti-Dyskinesia Agents
Antiparkinson Agents
Dopamine Agents
Excitatory Amino Acid Agents
Excitatory Amino Acid Antagonists
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Physiological Effects of Drugs processed this record on May 26, 2016