Memory Imaging of Normal Aging
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ClinicalTrials.gov Identifier: NCT00315575 |
Recruitment Status :
Completed
First Posted : April 18, 2006
Last Update Posted : January 26, 2009
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Condition or disease | Intervention/treatment |
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Alzheimer's Disease | Procedure: BOLD and Perfusion brain MRI |
The overall goals of this project are to identify consistent patterns of variance in brain function in patients at risk for Alzheimer's Disease by using APOE ε4 as a marker for disease risk. The activation Blood Oxygen Level Dependency (BOLD) signal will be compared to both resting and activation perfusion signals to assess the variability of cerebral blood flow as it relates to the BOLD signal. Each participant will be imaged on a 3T MRI scanner while performing an associate episodic memory task.
A total of 90 individuals will be recruited for this study. Participants will be non-demented, right handed, adults with or without at least one APOE ε4 allele. Groups will be split as follows: A) ages 25-39: non-ε4 (n=15); B) ages 25-39: +ε4 (n=15); C) ages 40-49: non-ε4 (n=15); D) ages 40-49: +ε4 (n=15);.E) ages 50-65: non-ε4: F) ages 50-65: +ε4 (n=15). These groups will be matched for mean age, mean years of education, gender distribution, as well as the presence or absence of a family history of AD in a first degree relative.
There will be 2 scanning sessions for each participant. Scan session #1 and Scan session #2 will be acquired within 2 weeks of each other and will take approximately one hour each.
Study Type : | Observational |
Estimated Enrollment : | 90 participants |
Observational Model: | Cohort |
Time Perspective: | Cross-Sectional |
Official Title: | BOLD and Perfusion fMRI of Alzheimer's Disease Risk |
Study Start Date : | August 2005 |
Actual Primary Completion Date : | July 2008 |
Actual Study Completion Date : | July 2008 |

Group/Cohort | Intervention/treatment |
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1
Individuals with high risk for Alzheimer's disease
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Procedure: BOLD and Perfusion brain MRI
Blood oxygenation and perfusion functional MRI performed twice, two weeks apart; each scan lasts 1 hour |
2
Individuals with low risk for Alzheimer's disease
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Procedure: BOLD and Perfusion brain MRI
Blood oxygenation and perfusion functional MRI performed twice, two weeks apart; each scan lasts 1 hour |
- identification of consistent patterns of variance in brain function in subjects at risk for Alzheimer's Disease by using APOE ε4 as a marker for disease risk [ Time Frame: single time point ]

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Ages Eligible for Study: | 25 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Right-handed
Exclusion Criteria:
- Major medical illnesses
- History of significant head trauma with residual cognitive deficits
- Other neurological or major psychiatric disorders such as schizophrenia, bipolar disorder, developmental learning disorder, and alcohol or substance abuse
- MRI contra-indications

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00315575
United States, California | |
Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego | |
La Jolla, California, United States, 92037 |
Principal Investigator: | Adam Fleisher, MD | University of California, San Diego |
Responsible Party: | Adam Fleisher, MD, University of California, San Diego |
ClinicalTrials.gov Identifier: | NCT00315575 |
Other Study ID Numbers: |
IA0092 5K23AG024062-02 ( U.S. NIH Grant/Contract ) |
First Posted: | April 18, 2006 Key Record Dates |
Last Update Posted: | January 26, 2009 |
Last Verified: | January 2009 |
Dementia brain circulation disease /disorder proneness /risk neuropathology neurophysiology aging |
apolipoprotein E genotype hemodynamics memory temporal lobe /cortex |
Alzheimer Disease Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases |
Tauopathies Neurodegenerative Diseases Neurocognitive Disorders Mental Disorders |