Usefulness of Markers to Predict Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation

The recruitment status of this study is unknown because the information has not been verified recently.

Verified April 2007 by University Hospital, Geneva.
Recruitment status was Active, not recruiting

Sponsor:

Information provided by:

University Hospital, Geneva

ClinicalTrials.gov Identifier:

NCT00315068

First received: April 13, 2006

Last updated: April 19, 2007

Last verified: April 2007

History of Changes

Purpose

Catheter ablation using radiofrequency is a new therapeutic tool to treat atrial fibrillation with a higher success rate than medical therapy (80% versus less than 50% respectively). Because of the length of the intervention and of the risk of complications of the procedure, it would be important to determine success rate before the intervention. The information gained from this study will in all probability improve our estimation of the chances of a successful intervention and may enable us to take necessary therapeutic measures in case of an elevated risk of recurrence.

Multiple studies suggest that the 2 markers in this study could provide information of this nature, however, their utility in the radiofrequency catheter ablation treatment of atrial fibrillation has never been demonstrated.

Condition
Atrial Fibrillation


Study Type:	Observational
Study Design:	Observational Model: Defined Population Primary Purpose: Screening Time Perspective: Longitudinal Time Perspective: Prospective
Official Title:	The Value of Amino-Terminal Brain Natriuretic Peptide and C-Reactive Protein Serum Levels for Predicting Recurrence of Atrial Fibrillation and/or Atrial Flutter After Radiofrequency Catheter Ablation

Resource links provided by NLM:

Genetics Home Reference related topics: familial atrial fibrillation

MedlinePlus related topics: Atrial Fibrillation

Genetic and Rare Diseases Information Center resources: Familial Atrial Fibrillation

U.S. FDA Resources

Further study details as provided by University Hospital, Geneva:


Estimated Enrollment:	180
Study Start Date:	April 2004
Estimated Study Completion Date:	August 2007

Detailed Description:

Catheter ablation of atrial fibrillation is a recent therapeutic tool to treat atrial fibrillation. The success rate of eliminating atrial fibrillation by radiofrequency catheter ablation is 80 %, after one or sometimes two procedures, against 20-50 % with drug treatment.

This intervention may be complicated by : hematoma at the puncture site – 1 % incidence; thromboembolic events < 1 % incidence; cardiac perforation with tamponade < 1 %, pulmonary vein stenosis 2 % incidence.

The aim of this study is to evaluate blood tests of biological products (NT-proBNP and CRP) as markers of prognosis and success after radiofrequency catheter ablation for atrial fibrillation.

Previous studies demonstrated the prognostic value of NT-proBNP and CRP in the recurrence of atrial fibrillation after electrical cardioversion. However the prognostic value of these biomarkers was never demonstrated in the setting of radiofrequency catheter ablation of atrial fibrillation.

This is an observation study including 180 patients with the indication of catheter ablation for atrial fibrillation. Confounding factors of increased NT-proBNP will be assessed with echocardiographic imaging.

Eligibility


Ages Eligible for Study:	18 Years to 80 Years (Adult, Senior)
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

atrial fibrillation
indication for catheter ablation of atrial fibrillation

Exclusion Criteria:

significant valvulopathy
previous catheter ablation for atrial fibrillation or atrial flutter
left ventricular ejection fraction < 30%
Severe heart failure (NYHA IV)
Severe enlargement of left atrium (> 55mm)

Contacts and Locations

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00315068

Locations


Switzerland
Cardiology Division University Hospital
Geneva, Switzerland, 1211

Sponsors and Collaborators

University Hospital, Geneva

Investigators


Principal Investigator:	Pierre-Frederic Keller, MD	Cardiology Division University Hospital

More Information


ClinicalTrials.gov Identifier:	NCT00315068 History of Changes
Other Study ID Numbers:	PRD-03-I-03
Study First Received:	April 13, 2006
Last Updated:	April 19, 2007
Health Authority:	Switzerland: Swissmedic

Keywords provided by University Hospital, Geneva:


arrythmia atrial fibrillation proteins

Additional relevant MeSH terms:


Atrial Fibrillation Recurrence Arrhythmias, Cardiac Heart Diseases	Cardiovascular Diseases Pathologic Processes Disease Attributes

ClinicalTrials.gov processed this record on September 29, 2016

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