We updated the design of this site on September 25th. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00313430
First Posted: April 12, 2006
Last Update Posted: August 21, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Erling Bjerregaard Pedersen, Regional Hospital Holstebro
  Purpose
The investigators want to test the hypothesis that patients with chronic renal disease have a poorer ability to preserve water after being thirsty and a poorer ability to excrete water after a load of fluid. They presume that these abilities become poorer when renal insufficiency progresses. The investigators further hypothesize that patients with hypertension also have a decreased ability to concentrate and dilute urine.

Condition
Renal Insufficiency, Chronic Hypertension

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease or Hypertension

Resource links provided by NLM:


Further study details as provided by Erling Bjerregaard Pedersen, Regional Hospital Holstebro:

Enrollment: 50
Study Start Date: May 2004
Primary Completion Date: March 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts
Dialysis patients
with or wthout glucose added to dialysis fluid

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Healthy participants were recruited by advertisements in public and private institutions Patients with primary hypertension or chronic renal failure were recruited from the Out-patients' Clinic, Department of Medicine, Section of Nephrology, Holstebro Hospital
Criteria

Inclusion Criteria:

  • Patients with chronic renal insufficiency, aged between 18 and 65, both men and women
  • Creatinine clearance between 30-59 ml/min
  • Patients with hypertension, aged between 18 and 65, both men and women; hypertension is defined as a mean arterial blood pressure in the daytime that is more than 140/90 mm Hg.
  • Healthy volunteers, aged between 18 and 65, both men and women

Exclusion Criteria:

  • Clinical signs or history of disease in the heart, lungs, liver, brain, and endocrine organs
  • Cancer
  • Alcohol abuse
  • Medicine abuse
  • Pregnancy
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00313430


Locations
Denmark
Department of Medicine, Holstebro Hospital
Holstebro, Ringkjoebing, Denmark, 7500
Sponsors and Collaborators
Erling Bjerregaard Pedersen
Investigators
Study Chair: Erling B Pedersen, Professor Holstebro, Holstebro, Denmark
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Erling Bjerregaard Pedersen, professor, chief physician, Regional Hospital Holstebro
ClinicalTrials.gov Identifier: NCT00313430     History of Changes
Other Study ID Numbers: MED. RES.HOS 2004 03/IT
First Submitted: April 11, 2006
First Posted: April 12, 2006
Last Update Posted: August 21, 2015
Last Verified: August 2015

Keywords provided by Erling Bjerregaard Pedersen, Regional Hospital Holstebro:
Urine concentration ability
chronic renal insufficiency
hypertension
aquaporin2
Patients with chronic renal insufficiency
Patients with hypertension
Healthy volunteers

Additional relevant MeSH terms:
Hypertension
Kidney Diseases
Renal Insufficiency
Renal Insufficiency, Chronic
Kidney Failure, Chronic
Vascular Diseases
Cardiovascular Diseases
Urologic Diseases