RATe Control in Atrial Fibrillation (RATAF)
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ClinicalTrials.gov Identifier: NCT00313157 |
Recruitment Status :
Completed
First Posted : April 12, 2006
Last Update Posted : May 13, 2014
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Atrial Fibrillation | Drug: Metoprolol Drug: Diltiazem Drug: Verapamil Drug: Carvedilol | Phase 3 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 80 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Single (Investigator) |
Primary Purpose: | Treatment |
Official Title: | Rate Control in Atrial Fibrillation |
Study Start Date : | April 2006 |
Actual Primary Completion Date : | September 2010 |
Actual Study Completion Date : | September 2010 |

Arm | Intervention/treatment |
---|---|
Active Comparator: Metoprolol
Treatment with Metoprolol 100 mg x 1 for three weeks
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Drug: Metoprolol
Other Name: Selo-Zok |
Active Comparator: Diltiazem
Treatment with Diltiazem 360 mg x 1 for three weeks
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Drug: Diltiazem
Other Name: Cardizem |
Active Comparator: Verapamil
Treatment with Verapamil 240 mg x 1 for three weeks
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Drug: Verapamil
Other Name: Isoptin Retard |
Active Comparator: Carvedilol
Treatment with Carvedilol 25 mg x 1 for three weeks
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Drug: Carvedilol
Other Name: Kredex |
- Ventricular rate [ Time Frame: Three weeks ]Ventricular rate evaluated after three weeks on study drug treatment

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Persistent or permanent atrial fibrillation with ventricular rate > 80/min at rest and/or > 100/min average at daytime.
- Male or female, age > 18.
Exclusion Criteria:
- Hypersensitivity or contraindication to metoprolol, verapamil, diltiazem or carvedilol.
- Coronary heart disease or heart failure
- Systolic blood pressure < 100 mmHg
- AV-conduction disturbance
- Severe hepatic or renal dysfunction
- Thyrotoxicosis
- Ongoing treatment with Digitalis
- Pregnancy or lactation

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00313157
Norway | |
Vestre Viken Hospital Trust, Baerum Hospital | |
Rud, Akershus, Norway, 1309 |
Principal Investigator: | Sara Reinvik Fagertun, MD | Asker and Baerum Hospital |
Responsible Party: | Sara Reinvik Ulimoe, MD, Asker & Baerum Hospital |
ClinicalTrials.gov Identifier: | NCT00313157 |
Other Study ID Numbers: |
2005-004221-26 |
First Posted: | April 12, 2006 Key Record Dates |
Last Update Posted: | May 13, 2014 |
Last Verified: | May 2014 |
Atrial fibrillation |
Atrial Fibrillation Arrhythmias, Cardiac Heart Diseases Cardiovascular Diseases Pathologic Processes Metoprolol Verapamil Carvedilol Diltiazem Anti-Arrhythmia Agents Antihypertensive Agents Sympatholytics Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs |
Adrenergic beta-1 Receptor Antagonists Adrenergic beta-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Antioxidants Protective Agents Calcium Channel Blockers Membrane Transport Modulators Calcium-Regulating Hormones and Agents Vasodilator Agents Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists |