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Allergy Towards Grass and Bronchial Inflammation - Related to Immunotherapy and Exhaled Nitrogen Oxide

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ClinicalTrials.gov Identifier: NCT00312312
Recruitment Status : Unknown
Verified September 2006 by Bispebjerg Hospital.
Recruitment status was:  Recruiting
First Posted : April 10, 2006
Last Update Posted : June 12, 2007
Sponsor:
Information provided by:
Bispebjerg Hospital

Brief Summary:
The purpose of this study is to evaluate the immunomodulatory effect of treatment of allergic rhinitis symptoms with specific immunotherapy by measurement of pulmonary inflammatory markers, and among others, exhaled nitric oxide.

Condition or disease Intervention/treatment Phase
Asthma, Bronchial Allergic Rhinitis Hypersensitivity, Immediate Biological: Specific immunotherapy Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Does Specific Immunotherapy Possess Immunomodulative Effects at the Bronchial Mucosa Level Among Adults With Atopic Diseases?
Study Start Date : March 2006
Estimated Study Completion Date : December 2008



Primary Outcome Measures :
  1. Skin prick test
  2. Spirometry
  3. Methacholine provocation of the pulmonary system
  4. Exhaled nitric oxide
  5. Immunoglobulin E (IgE) status
  6. Sputum examination
  7. Condensation of exhaled air

Secondary Outcome Measures :
  1. Questionnaire


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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age 18-45 years old
  • Skin prick test or RAS test and physical examination conclude that the patient will have a beneficial effect from specific immunotherapy

Exclusion Criteria:

  • Other diseases except atopic disease
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00312312


Contacts
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Contact: Thomas B Knudsen, Medical student +45 61 70 96 99 thomas@uknet.dk
Contact: Vibeke Backer, M.D., M.D.Sci +45 35 31 30 69 backer@dadlnet.dk

Locations
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Denmark
Bispebjerg Hospital Recruiting
Copenhagen, Denmark, 2400 NV
Contact: Thomas B Knudsen, Medical student    +45 61 70 96 99    thomas@uknet.dk   
Sub-Investigator: Thomas B Knudsen, Medical student         
Sponsors and Collaborators
Bispebjerg Hospital
Investigators
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Principal Investigator: Vibeke Backer, M.D., M.D.Sci Lungeforskningsenheden v/Bispebjerg hospital

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ClinicalTrials.gov Identifier: NCT00312312     History of Changes
Other Study ID Numbers: SITNO
First Posted: April 10, 2006    Key Record Dates
Last Update Posted: June 12, 2007
Last Verified: September 2006

Keywords provided by Bispebjerg Hospital:
Asthma
Allergic rhinitis
Atopy
Exhaled nitric oxide
Specific immunotherapy
Atopic diseases

Additional relevant MeSH terms:
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Rhinitis
Rhinitis, Allergic
Hypersensitivity
Asthma
Hypersensitivity, Immediate
Nose Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases
Respiratory Hypersensitivity
Immune System Diseases
Bronchial Diseases
Lung Diseases, Obstructive
Lung Diseases
Immunologic Factors
Physiological Effects of Drugs