Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets in Acute Bacterial Cystitis.
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|ClinicalTrials.gov Identifier: NCT00305071|
Recruitment Status : Unknown
Verified March 2006 by Min-Sheng General Hospital.
Recruitment status was: Not yet recruiting
First Posted : March 21, 2006
Last Update Posted : March 21, 2006
In conventional treatment for non-complicated bacterial cystitis, 3-day oral antibiotics could achieve good cure rate. However, severe lower urinary tract symptoms were most bothersome and only could be partially relieved by NSAID, detrusor muscle relaxants, minor tranquilizer or pyridium. Some medication associated side effects were complained while receiving adjuvant medication treatment, including gastro-intestinal discomfort, dry mouth, blurred vision, lethargy, or allergic reactions. The irritative bladder symptoms from bladder inflammation had great impact on the quality of life and well tolerable adjuvant therapy would have clinical benefit to reduce the discomfort from the bladder.
In the past years, cranberry juice or its extract has been proven to have protective effect on urothelium to prevent further bacterial ascending infection. The commercial cranberry extract tablets have good tolerability and showed good effect on symptoms reliving and infection protection on several clinical observation. In acute bladder infection, we could expect the bioactive components in cranberry could reduce the virulence of pathogens and assist to eradicate pathogens and to stable the urothelium. In literature review, only little works focusing on the symptoms relief in acute cystitis patients. To clarify the clinical benefit on lower urinary symptoms relieving, we attempt to conduct a randomized double-blind placebo-controlled trial to evaluate the effect of a compound cranberry extract tablet as an adjunctive modality in treating acute uncomplicated bacterial cystitis in otherwise healthy female patients.
|Condition or disease||Intervention/treatment||Phase|
|Pyuria Urinary Tract Infections||Drug: compound cranberry extract tablet||Phase 2|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets (UmayC) in Acute Bacterial Cystitis.|
|Study Start Date :||April 2006|
- Time to symptoms relief
- Pyuria eradication rate
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00305071
|Contact: Po-Chien Huang, MD||886-3-3179599 ext firstname.lastname@example.org|
|Contact: Hung-Ju Yang, MD||886-3-3179599 ext email@example.com|
|Min-Sheng General Hospital||Not yet recruiting|
|Taoyuan City, Taiwan, 320|
|Contact: Po-Chien Huang, MD 886-3-3179599 ext 8223 firstname.lastname@example.org|
|Principal Investigator:||Po-Chien Huang, MD||Division of Urology, department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan|