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Dynamic Light Scattering to Study Crystalline Proteins in Young Normal Lenses

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00304967
First Posted: March 20, 2006
Last Update Posted: July 2, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institutes of Health Clinical Center (CC)
  Purpose

This study will use a method called dynamic light scattering (DLS) to study the lens of the eye in young normal subjects. The DLS device uses a very dim laser light to study the lens of the eye. It detects proteins in the lens, identifying early changes that may make the device useful in future cataract studies. This study will use DLS to examine the characteristics of proteins in healthy young lenses that can be used for comparison with lenses in older people and people with cataracts.

Normal volunteers aged 5 to 21 years may be eligible for this study. Participants undergo the following procedures:

Medical history

Eye examination with dilation to include:

  • Measurement of visual acuity
  • Examination of pupils and eye movements
  • Examination of the front of the eye (cornea, lens) with a slit lamp bio-microscope
  • Examination of retina with an ophthalmoscope (instrument with a strong light and magnifying lens)
  • Dynamic light scattering

Condition
Healthy

Study Type: Observational
Official Title: A Study of Crystalline Proteins in Young Normal Lenses Using the NASA-NEI Dynamic Light Scattering (DLS) Device

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 30
Study Start Date: March 15, 2006
Estimated Study Completion Date: March 31, 2007
Detailed Description:
The NASA-NEI Dynamic Light Scattering (DLS) device detects early molecular lens changes before clinical means are able to detect any lens changes in animal and limited human studies. This ability will make it very useful in future clinical studies of cataract etiology as well as treatment. A recently concluded clinical cross sectional study of lenses (in vivo) using the DLS device showed good reproducibility and good correlation with clinical cataract grading. It also detected remarkable changes in the lens crystalline proteins with aging and with cataract formation. We therefore propose to study the characteristics of the crystalline proteins in pristine young normal lenses with DLS for comparison with aging and cataractous lens findings. We will examine 30 young normal subjects, perform undilated eye examinations, and obtain DLS measurements of their lenses. We will then use these DLS measurements for comparison with the previously obtained aging and cataract DLS measurements, to obtain normative data for future lens and cataract clinical studies.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   5 Years to 21 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
  • INCLUSION CRITERIA

The study will enroll 30 normal control subjects, aged 5-21 years. Eligible participants must have normal clear lenses as determined by the eye examination.

EXCLUSION CRITERIA

Individuals who cannot cooperate or keep still for the DLS measurements will be excluded.

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00304967


Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Eye Institute (NEI)
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00304967     History of Changes
Other Study ID Numbers: 060117
06-EI-0117
First Submitted: March 18, 2006
First Posted: March 20, 2006
Last Update Posted: July 2, 2017
Last Verified: March 31, 2007

Keywords provided by National Institutes of Health Clinical Center (CC):
Cataract
Normal Lenses
Lens Crystallines
Dynamic or Quasielastic Light Scattering (DLS)
Eye Examinations
Healthy Volunteer
HV
Eye Examination