Fecal Bacterial Flora in Clostridium Difficile-Associated Diarrhea
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Clostridium difficile associated colitis is an increasing problem in hospitals throughout the developed world; the number of cases has increased, and the failure to respond to conventional therapy has become far more common. The investigators have recently documented in the medical literature (Clin Infect Dis, June, 2005; Lancet Infect Dis, August, 2005). Possible reasons for failure of treatment include persistence of C. difficile and/or imbalance of other bacterial flora in the colon. The bacteriology of fecal flora in C. difficile associated diarrhea has not been studied.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients positive for C. difficile
Patients with antibiotic-associated diarrhea with a positive assay for C. difficile toxin
Patients with antibiotic-associated diarrhea with 3 negative assays for C. difficile toxin
Patients with antibiotic-associated diarrhea that has failed to respond to conventional therapy
Hospitalized patients who have received >2 antibiotics and who have no symptoms of diarrhea or abdominal discomfort