Assessment of the Ability to Distinguish Odors in Glaucoma Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00304824
Recruitment Status : Completed
First Posted : March 20, 2006
Last Update Posted : September 26, 2008
Information provided by:
University Hospital, Basel, Switzerland

Brief Summary:
Glaucoma is one of the leading causes of blindness worldwide. The key feature of glaucoma is damage to the optic nerve head with loss of retinal ganglion cells and local tissue remodeling. Neuronal cell death in glaucoma occurs by apoptotic mechanisms1. Apoptosis of neurons also plays a major role in neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. An association between glaucoma and these disorders has been described 2-4. Furthermore, it has been reported that the olfactory function is disturbed in these neurodegenerative diseases5-6. We hypothesize that similar olfactory alterations may occur in glaucoma which is in fact a local neurodegenerative disease.

Condition or disease

  Show Detailed Description

Study Type : Observational
Actual Enrollment : 30 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Olfactory Function in Glaucoma Patients
Study Start Date : October 2004
Actual Study Completion Date : November 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Glaucoma
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   17 Years to 70 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
glaucoma patients

Inclusion Criteria:

Chronic open-angle glaucoma with typical glaucomatous disc and visual field damage.

Exclusion Criteria:

  • Occludable iridocorneal angles
  • History of current, chronic or recurrent inflammatory eye disease
  • History of retinal or neuroophthalmologic disease that could result in visual field defects
  • Need for any concomitant medications that may interfere with the evaluation of olfactory function
  • Patients with a significant history and/or active alcohol or drug abuse (significant is defined as that which in the opinion of the investigator may either put the patient at risk because of participation in the study or may influence the results of the study or the patient's ability to participate in the study), smokers
  • History of olfactory disturbance related to identifiable local factors and any local condition that could lead to hyposmia/anosmia or interfere with the olfactory function, such as polyps, chronic sinus infection, sub(acute) viral or bacterial infection, history of sinus surgery

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00304824

Sponsors and Collaborators
University Hospital, Basel, Switzerland
Study Director: Selim Orgul University Eye Hospital Basel, Switzerland

Additional Information:
Responsible Party: Selim Orgül, MD, University Hospital, Basel, Switzerland Identifier: NCT00304824     History of Changes
Other Study ID Numbers: 009-Guk-2004-002
First Posted: March 20, 2006    Key Record Dates
Last Update Posted: September 26, 2008
Last Verified: September 2008

Keywords provided by University Hospital, Basel, Switzerland:
Olfactory functions
Sniffing Sticks Test

Additional relevant MeSH terms:
Ocular Hypertension
Eye Diseases