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Assessment of the Ability to Distinguish Odors in Glaucoma Patients

This study has been completed.
Information provided by:
University Hospital, Basel, Switzerland Identifier:
First received: March 17, 2006
Last updated: September 25, 2008
Last verified: September 2008
Glaucoma is one of the leading causes of blindness worldwide. The key feature of glaucoma is damage to the optic nerve head with loss of retinal ganglion cells and local tissue remodeling. Neuronal cell death in glaucoma occurs by apoptotic mechanisms1. Apoptosis of neurons also plays a major role in neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. An association between glaucoma and these disorders has been described 2-4. Furthermore, it has been reported that the olfactory function is disturbed in these neurodegenerative diseases5-6. We hypothesize that similar olfactory alterations may occur in glaucoma which is in fact a local neurodegenerative disease.


Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Olfactory Function in Glaucoma Patients

Resource links provided by NLM:

Further study details as provided by University Hospital, Basel, Switzerland:

Enrollment: 30
Study Start Date: October 2004
Study Completion Date: November 2005
  Show Detailed Description


Ages Eligible for Study:   17 Years to 70 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
glaucoma patients

Inclusion Criteria:

Chronic open-angle glaucoma with typical glaucomatous disc and visual field damage.

Exclusion Criteria:

  • Occludable iridocorneal angles
  • History of current, chronic or recurrent inflammatory eye disease
  • History of retinal or neuroophthalmologic disease that could result in visual field defects
  • Need for any concomitant medications that may interfere with the evaluation of olfactory function
  • Patients with a significant history and/or active alcohol or drug abuse (significant is defined as that which in the opinion of the investigator may either put the patient at risk because of participation in the study or may influence the results of the study or the patient's ability to participate in the study), smokers
  • History of olfactory disturbance related to identifiable local factors and any local condition that could lead to hyposmia/anosmia or interfere with the olfactory function, such as polyps, chronic sinus infection, sub(acute) viral or bacterial infection, history of sinus surgery
  Contacts and Locations
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Please refer to this study by its identifier: NCT00304824

Sponsors and Collaborators
University Hospital, Basel, Switzerland
Study Director: Selim Orgul University Eye Hospital Basel, Switzerland
  More Information

Additional Information:
Responsible Party: Selim Orgül, MD, University Hospital, Basel, Switzerland Identifier: NCT00304824     History of Changes
Other Study ID Numbers: 009-Guk-2004-002
Study First Received: March 17, 2006
Last Updated: September 25, 2008

Keywords provided by University Hospital, Basel, Switzerland:
Olfactory functions
Sniffing Sticks Test

Additional relevant MeSH terms:
Ocular Hypertension
Eye Diseases processed this record on July 19, 2017